OBJECTIVE To assess subtypes of depressive symptoms and their relationship with cardiovascular disease (CVD) morbidity among CVD risk persons. METHODS A prospective study of 2522 CVD risk persons was conducted. Non-melancholic and melancholic depressive symptoms were assessed by Beck's Depression Inventory. Data on incident CVD was gathered from a national register, after 8 years of follow-up. RESULTS At baseline, the prevalence of non-melancholic and melancholic depressive symptoms was 14.9% and 5.2%, respectively. A total of 18,413 person-years was followed up, and the incidence of CVD was 9.6% in non-depressive, 14.1% in non-melancholically depressive, and 13.0% in melancholically depressive subjects. When adjusted for age, gender, education, smoking, alcohol use, leisure-time physical activity, hypertension, and dyslipidemia, the incidence rate ratios (IRR) for CVD in subjects with non-melancholic and melancholic depressive symptoms compared to non-depressiveness were IRR 1.69 (95% CI: 1.23-2.31) and IRR 1.31 (95% CI: 0.75-2.26). CONCLUSION Non-melancholic depressive symptoms seem to increase risk for incident CVD among CVD risk subjects. Considering non-melancholic depressive symptoms might be useful when treating subjects with other CVD risk factors.

中文翻译：

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非忧郁性抑郁症状增加心血管疾病发病风险：一项针对有心血管疾病和 2 型糖尿病风险的初级保健人群的前瞻性研究

目的 评估 CVD 风险人群中抑郁症状的亚型及其与心血管疾病 (CVD) 发病率的关系。方法 对 2522 名 CVD 风险人群进行了前瞻性研究。通过贝克抑郁量表评估非忧郁和忧郁抑郁症状。经过 8 年的随访，CVD 事件的数据是从国家登记处收集的。结果 在基线时，非忧郁和忧郁抑郁症状的患病率分别为 14.9% 和 5.2%。共随访 18,413 人年，非抑郁患者 CVD 发生率为 9.6%，非忧郁抑郁患者为 14.1%，忧郁抑郁患者为 13.0%。根据年龄、性别、教育程度、吸烟、饮酒、闲暇时间的体力活动、高血压和血脂异常进行调整后，与非抑郁症相比，具有非忧郁和忧郁抑郁症状的受试者的 CVD 发生率比 (IRR) 为 IRR 1.69 (95% CI: 1.23-2.31) 和 IRR 1.31 (95% CI: 0.75-2.26)。结论 非忧郁性抑郁症状似乎会增加 CVD 风险受试者发生 CVD 的风险。在治疗具有其他 CVD 风险因素的受试者时，考虑非忧郁性抑郁症状可能有用。