2,2,2-Trifluorodiazoethane (CF3CHN2): A Long Journey since 1943.,Chemical Reviews

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2,2,2-Trifluorodiazoethane (CF3CHN2): A Long Journey since 1943.
Chemical Reviews ( IF 51.4 ) Pub Date : 2020-09-17 , DOI: 10.1021/acs.chemrev.0c00406
Pavel K Mykhailiuk _{1,

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Affiliation

2,2,2-Trifluorodiazoethane (CF₃CHN₂) has been proven to be a valuable reagent for the rapid synthesis of various classes of trifluoromethyl-substituted organic molecules in both academic and industrial research. The reagent was prepared first in 1943, but only recently it received a great attention from the scientific community. Protocols for in situ generation, in flow generation, and crystalline analogues of CF₃CHN₂ were developed during the past decade and have led to an ever-increasing number of publications on the topic. The current review summarizes and comprehensively analyzes all manuscripts in a peer-reviewed literature on 2,2,2-trifluorodiazoethane since its discovery in 1943 until today (as of 19 June 2020). These include contributions mostly overseen by scientific community before. A particular emphasis of this review is to classify the existing reactivity modes of CF₃CHN₂ and to systematically analyze the corresponding reaction mechanisms in details. At the end of this review, several undeveloped areas for CF₃CHN₂ are outlined, based on the overseen precedents in the literature.

中文翻译：

2,2,2-三氟重氮乙烷（CF3CHN2）：自1943年以来的漫长旅程。

2,2,2-三氟重氮乙烷（CF ₃ CHN ₂）在学术和工业研究中已被证明是用于快速合成各种类型的三氟甲基取代的有机分子的有价值的试剂。该试剂于1943年首次制备，但直到最近它才受到科学界的极大关注。CF ₃ CHN _2的原位生成，流程生成协议和晶体类似物在过去的十年中开发出来，导致有关该主题的出版物数量不断增加。自从1943年发现至今（截至2020年6月19日），本综述总结并全面分析了有关2,2,2-三氟重氮乙烷的同行评审文献中的所有手稿。这些包括以前主要由科学界监督的贡献。这项审查的一个特别重点是对CF ₃ CHN ₂的现有反应模式进行分类，并详细系统地分析相应的反应机理。在本文的最后，根据文献中的先例，概述了CF ₃ CHN _2的几个未开发领域。

更新日期：2020-11-25

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