Photothermal Therapy Combined with Light-Induced Generation of Alkyl Radicals for Enhanced Efficacy of Tumor Treatment,ACS Applied Polymer Materials

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Photothermal Therapy Combined with Light-Induced Generation of Alkyl Radicals for Enhanced Efficacy of Tumor Treatment
ACS Applied Polymer Materials ( IF 4.4 ) Pub Date : 2020-09-17 , DOI: 10.1021/acsapm.0c00832
Qihang Wu _{1,

2} , Jinfeng Han ₁ , Chaonan Li _{1,

2} , Tingting Sun ₁ , Zhigang Xie _{1,

2}

Affiliation

Photothermal therapy (PTT) shows great potential in tumor treatment, but the harsh photothermal heating might give rise to irreversible damage to peripheral normal tissues. Combining PTT with the alkyl radicals generated from the thermal degradation of azo initiators should be a good candidate for tumor therapy. Herein, semiconducting polymer nanoparticles (PBT NPs) with good photothermal conversion ability and photothermal stability have been developed as the photothermal agent. Under near-infrared light irradiation, the heat generated by PBT NPs could decompose 2,2′-azobis[2-(2-imidazolin-2-yl)propane] dihydrochloride into alkyl radicals, which could enhance the therapeutic effect of PTT under mild conditions. The combination of PTT and alkyl radicals provides a promising strategy to alleviate the side effects caused by hyperthermia and improve the treatment effect of PTT.

中文翻译：

光热疗法结合光诱导生成的烷基自由基增强了肿瘤治疗的功效

光热疗法（PTT）在肿瘤治疗中显示出巨大的潜力，但是苛刻的光热加热可能会对周围的正常组织造成不可逆转的损害。将PTT与偶氮引发剂热降解产生的烷基结合起来，应该是肿瘤治疗的良好选择。在此，已经开发出具有良好的光热转化能力和光热稳定性的半导体聚合物纳米颗粒（PBT NP）作为光热剂。在近红外光照射下，PBT NPs产生的热量可以将2,2'-偶氮双[2-（2-咪唑啉-2-基）丙烷]二盐酸盐分解为烷基基团，在温和的条件下可以增强PTT的治疗效果。条件。

更新日期：2020-10-11

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