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Ball-Bearing-Inspired Polyampholyte-Modified Microspheres as Bio-Lubricants Attenuate Osteoarthritis.
Small ( IF 13.0 ) Pub Date : 2020-09-17 , DOI: 10.1002/smll.202004519
Jielai Yang 1, 2 , Ying Han 3 , Jiawei Lin 1, 2 , Yuan Zhu 2 , Fei Wang 1 , Lianfu Deng 1 , Hongyu Zhang 3 , Xiangyang Xu 2 , Wenguo Cui 1
Small ( IF 13.0 ) Pub Date : 2020-09-17 , DOI: 10.1002/smll.202004519
Jielai Yang 1, 2 , Ying Han 3 , Jiawei Lin 1, 2 , Yuan Zhu 2 , Fei Wang 1 , Lianfu Deng 1 , Hongyu Zhang 3 , Xiangyang Xu 2 , Wenguo Cui 1
Affiliation
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Osteoarthritis, a lubrication dysfunction related disorder in joint, is characterized by articular cartilage degradation and joint capsule inflammation. Enhancing joint lubrication, combined with anti‐inflammatory therapy, is considered as an effective strategy for osteoarthritis treatment. Herein, based on the ball‐bearing‐inspired superlubricity and the mussel‐inspired adhesion, a superlubricated microsphere, i.e., poly (dopamine methacrylamide‐to‐sulfobetaine methacrylate)‐grafted microfluidic gelatin methacrylate sphere (MGS@DMA‐SBMA), is developed by fabricating a monodisperse, size‐uniform microsphere using the microfluidic technology, and then a spontaneously modified microsphere with DMA‐SBMA copolymer by a one‐step biomimetic grafting approach. The microspheres are endowed with enhanced lubrication due to the tenacious hydration layer formed around the charged headgroups (‐N+(CH3)2‐ and ‐SO3−) of the grafted poly sulfobetaine methacrylate (pSBMA), and simultaneously are capable of efficient drug loading and release capability due to their porous structure. Importantly, the grafting of pSBMA enables the microspheres with preferable properties (i.e., enhanced lubrication, reduced degradation, and sustained drug release) that are highly desirable for intraarticular treatment of osteoarthritis. In addition, when loaded with diclofenac sodium, the superlubricated microspheres with excellent biocompatibility can inhibit the tumor necrosis factor α (TNF‐α)‐induced chondrocyte degradation in vitro, and further exert a therapeutic effect toward osteoarthritis in vivo.
中文翻译:
含滚珠的聚两性电解质修饰的微球作为生物润滑剂可减轻骨关节炎。
骨关节炎是与关节润滑功能障碍有关的疾病,其特征是关节软骨退化和关节囊发炎。加强关节润滑并结合抗炎治疗被认为是治疗骨关节炎的有效策略。在此,基于滚珠轴承启发的超润滑性和贻贝启发的附着力,开发了一种超润滑的微球,即聚(多巴胺甲基丙烯酰胺-磺基甜菜碱甲基丙烯酸酯)接枝的微流明胶甲基丙烯酸球(MGS @ DMA-SBMA)通过使用微流体技术制造尺寸大小均匀的单分散微球,然后通过一步仿生接枝方法用DMA-SBMA共聚物自发修饰微球。+(CH 3)2 -和-SO 3 - )的接枝的聚磺基甜菜碱甲基丙烯酸酯(pSBMA)的,并且同时能够有效的药物加载和释放能力,由于其多孔结构。重要的是,pSBMA的接枝使微球具有理想的特性(即增强的润滑性,减少的降解和持续的药物释放),这些特性对于关节内治疗骨关节炎是非常需要的。此外,当具有双氯芬酸钠时,具有优异生物相容性的超润滑微球可以在体外抑制肿瘤坏死因子α(TNF-α)诱导的软骨细胞降解,并进一步在体内对骨关节炎发挥治疗作用。
更新日期:2020-11-06
中文翻译:
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含滚珠的聚两性电解质修饰的微球作为生物润滑剂可减轻骨关节炎。
骨关节炎是与关节润滑功能障碍有关的疾病,其特征是关节软骨退化和关节囊发炎。加强关节润滑并结合抗炎治疗被认为是治疗骨关节炎的有效策略。在此,基于滚珠轴承启发的超润滑性和贻贝启发的附着力,开发了一种超润滑的微球,即聚(多巴胺甲基丙烯酰胺-磺基甜菜碱甲基丙烯酸酯)接枝的微流明胶甲基丙烯酸球(MGS @ DMA-SBMA)通过使用微流体技术制造尺寸大小均匀的单分散微球,然后通过一步仿生接枝方法用DMA-SBMA共聚物自发修饰微球。+(CH 3)2 -和-SO 3 - )的接枝的聚磺基甜菜碱甲基丙烯酸酯(pSBMA)的,并且同时能够有效的药物加载和释放能力,由于其多孔结构。重要的是,pSBMA的接枝使微球具有理想的特性(即增强的润滑性,减少的降解和持续的药物释放),这些特性对于关节内治疗骨关节炎是非常需要的。此外,当具有双氯芬酸钠时,具有优异生物相容性的超润滑微球可以在体外抑制肿瘤坏死因子α(TNF-α)诱导的软骨细胞降解,并进一步在体内对骨关节炎发挥治疗作用。