Bacterial Lectin-Targeting Glycoconjugates for Selective Elimination of Pathogenic Bacteria,ACS Macro Letters

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Bacterial Lectin-Targeting Glycoconjugates for Selective Elimination of Pathogenic Bacteria
ACS Macro Letters ( IF 5.1 ) Pub Date : 2020-09-15 , DOI: 10.1021/acsmacrolett.0c00454
Ji Young Hyun _{1,

2} , Chang-Hee Lee ₁ , Hosoowi Lee ₁ , Woo-Dong Jang ₁ , Injae Shin ₁

Affiliation

Herein we report a strategy to eradicate pathogenic bacteria selectively, which utilizes bacterial lectin-targeting glycoconjugates that contain an epitope or a photosensitizer to promote antibody-dependent cellular cytotoxicity (ADCC) or photodynamic therapy (PDT), respectively. Our results show that death promoted by using the designed synthetic glycoconjugates coupled with ADCC or PDT takes place selectively in pathogenic bacteria expressing lectins on their surfaces.

中文翻译：

细菌凝集素靶向糖结合物用于选择性消除病原细菌

在本文中，我们报告了一种策略，以选择性地根除病原细菌，该策略利用包含表位或光敏剂的细菌凝集素靶向糖缀合物分别促进抗体依赖性细胞毒性（ADCC）或光动力疗法（PDT）。我们的结果表明，通过使用设计的合成糖缀合物与ADCC或PDT结合而促进的死亡是在表面表达凝集素的致病细菌中选择性发生的。

更新日期：2020-10-21

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