In this work, a new type of hollow MnFeO oxide derived obtained from the metal-organic framework (MOF)@MOF was designed and proposed, which has intrinsic activity of mimicking enzymes of oxidase and peroxidase by adjustment pH values. Based on the colorimetric reaction and the hindrance of the oxidase-like activity in the presence of L-cysteine (Cys), as well as the recovery of oxidase-like activity due to the specific complexation of Cys and mercury (II) ions (Hg²⁺), a new type of colorimetric transmission platform for Cys and Hg²⁺ detection with wide linear ranges of 1-25 μM for Cys and 0.1-15 μM for Hg²⁺ has been developed. Besides, a better colorimetric sensing platform for detecting H₂O₂ was established with linear ranges of 1-60 μM and 60-300 μM based on generating hydroxyl radicals (·OH). Furthermore, the hollow MnFeO oxide has high stability, excellent selectivity with good activity over a long period of time. Surprisingly, the proposed method for Cys, Hg²⁺ and H₂O₂ estimation can also be used in actual samples. These characteristics lay a foundation for further investigation about the catalytic activity of the hollow MnFeO oxide nanomaterials and make it show broad prospects in the field of biosensing and catalysis.

在这项工作中，设计并提出了一种新型的由金属-有机骨架（MOF）@MOF获得的中空MnFeO氧化物，它具有通过调节pH值来模仿氧化酶和过氧化物酶的固有活性。基于比色反应和L-半胱氨酸（Cys）存在下氧化酶样活性的阻碍，以及由于Cys和汞（II）离子（Hg）的特定络合而恢复的氧化酶样活性²⁺），新类型的Cys和Hg比色传输平台²⁺检测与Cys和0.1-15μM汞1-25μM的宽线性范围²⁺已经研制成功。此外，还有更好的比色传感平台可检测H ₂ O ₂基于产生羟基自由基（·OH）的线性范围为1-60μM和60-300μM。此外，中空的MnFeO氧化物具有高的稳定性，优异的选择性以及长期良好的活性。令人惊讶地，所提出的用于Cys，Hg ²⁺和H ₂ O ₂估计的方法也可以在实际样品中使用。这些特性为进一步研究中空MnFeO氧化物纳米材料的催化活性奠定了基础，使其在生物传感和催化领域显示出广阔的前景。