An Orally Administered CeO2@Montmorillonite Nanozyme Targets Inflammation for Inflammatory Bowel Disease Therapy,Advanced Functional Materials

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An Orally Administered CeO2@Montmorillonite Nanozyme Targets Inflammation for Inflammatory Bowel Disease Therapy
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2020-09-13 , DOI: 10.1002/adfm.202004692
Sheng Zhao ₁ , Yixuan Li ₂ , Quanyi Liu _{3,

4} , Sirong Li ₁ , Yuan Cheng ₁ , Chaoqun Cheng ₁ , Ziying Sun ₂ , Yan Du _{3,

4} , Christopher J. Butch ₁ , Hui Wei _{1,

5,

6}

Affiliation

Safe, effective, and convenient administration of therapeutic nanomaterials is one of the greatest difficulties in nanomedicine. To tackle this challenge, a system which couples multi‐enzyme mimicking CeO₂ nanoparticles with clinically approved montmorillonite (MMT) for inflammatory bowel disease (IBD) therapy is reported. CeO₂ exhibits superoxide dismutase‐ and catalase‐like activities, and hydroxyl radical scavenging activity, making it more efficient at scavenging reactive oxygen species (ROS) than non‐catalytic antioxidants while being more stable than free enzymes. In addition, negatively‐charged MMT can be orally administered and specifically adsorbed onto positively‐charged inflamed colon tissue via electrostatic interactions for targeted delivery. When the two are assembled together by in situ growth of CeO₂ onto MMT, the optimized CeO₂@MMT(1:9) is stable in the stomach for oral delivery, targets the inflamed colon through electrostatic interactions, and reduces inflammation through ROS scavenging, all without any significant systemic exposure as demonstrated by the relief of murine IBD in vivo.

中文翻译：

口服管理的CeO2 @蒙脱土纳米酶靶向炎症，用于炎症性肠病治疗。

安全，有效和方便地施用治疗性纳米材料是纳米医学中的最大困难之一。为了应对这一挑战，已报道了一种将模仿CeO ₂纳米粒子的多酶与临床批准的用于炎症性肠病（IBD）的蒙脱石（MMT）结合的系统。铈₂具有超氧化物歧化酶和过氧化氢酶样活性以及清除羟自由基的活性，使其比非催化抗氧化剂更有效地清除活性氧（ROS），同时比游离酶更稳定。此外，可以口服带负电荷的MMT，并通过静电相互作用将其特异性吸附在带正电荷的发炎结肠组织上，以进行靶向递送。当通过在MMT上原位生长CeO ₂将两者组装在一起时，优化的CeO ₂ @MMT（1：9）在胃中可以稳定地用于口服递送，通过静电相互作用靶向发炎的结肠，并通过清除ROS减少炎症，这些都没有任何明显的全身性暴露，如体内减轻鼠IBD所证明的。

更新日期：2020-11-04

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