2S albumin proteins are a group of important seed storage proteins (SSPs) essential to seeds at early and late developmental stages, by providing amino acids and other nutrients during germination and for seed defense. 2S albumins possess a well-conserved cysteine supporting the stability of temperature, pH, and proteolysis. The 3D structure rich in alpha-helices and positively charged is particularly suited for antibacterial and antifungal activity, which is presented by many 2S albumins. However, the hypervariable region present in 2S albumins induces allergenic reactions. Because of that, 2S albumins have never been recognized for their biotechnological potential. However, the development of servers used for the rational design of antimicrobial molecules has now brought a new application to 2S albumins, acting as a model to design antimicrobial molecules without the toxic or allergenic effects of 2S albumins. Therefore, this review is focused on discussing the importance of 2S albumins to seed development and defense and the biochemical, structural and functional properties of these proteins thought to play a role in their antimicrobial activity. Additionally, the application of 2S albumins to design synthetic antimicrobial peptides is discussed, potentially bringing new functions to these forgotten proteins.

2S白蛋白蛋白是一组重要的种子存储蛋白（SSP），它们在种子的早期和后期发育阶段都是必需的，通过在发芽过程中提供氨基酸和其他营养物质以及种子防御作用。2S白蛋白具有保存良好的半胱氨酸，支持温度，pH和蛋白水解的稳定性。富含α-螺旋且带正电荷的3D结构特别适合抗菌和抗真菌活性，这是许多2S白蛋白所呈现的。但是，存在于2S白蛋白中的高变区会引起过敏反应。因此，从未发现2S白蛋白具有其生物技术潜力。但是，用于合理设计抗微生物分子的服务器的开发现已为2S白蛋白带来了新的应用，用作设计抗微生物分子的模型，而没有2S白蛋白的毒性或过敏原作用。因此，本综述着重讨论2S白蛋白对种子发育和防御的重要性，以及认为这些蛋白在其抗菌活性中起作用的这些蛋白的生化，结构和功能特性。此外，讨论了2S白蛋白在设计合成抗菌肽中的应用，可能为这些被遗忘的蛋白质带来新的功能。