Abstract In order to create novel potent antifungal agents, the antifungal effects of 6-bromo-4-ethoxyethylthio quinazoline on plant pathogenic fungi were evaluated by mycelial growth rate method. The bioassay results showed that title compound possesses high antifungal activities on fungi with EC50 values ranging from 17.47 to 70.79 μg/mL. The mechanism of action of 6-bromo-4-ethoxyethylthio quinazoline against fungi was studied in Gibberella zeae model. After treated with title compound at 100 μg/mL for 12 h, the mycelial reducing sugar, chitosan, soluble protein and pyruvate content, chitinase activity showed declining tendency.

中文翻译：

---

6-溴-4-乙氧基乙硫基喹唑啉的抗真菌生物活性

摘要 为研制新型强效抗真菌剂，采用菌丝生长速率法评价6-溴-4-乙氧基乙硫基喹唑啉对植物病原真菌的抗真菌作用。生物测定结果表明，标题化合物对真菌具有较高的抗真菌活性，EC50 值范围为 17.47 至 70.79 μg/mL。6-bromo-4-ethoxyethylthioquinazoline 对真菌的作用机制在赤霉病模型中进行了研究。标题化合物100 μg/mL处理12 h后，菌丝体还原糖、壳聚糖、可溶性蛋白和丙酮酸含量、几丁质酶活性呈下降趋势。