A facile, efficient, solvent-free method for the synthesis of phosphocholines and lyso phosphocholines in excellent yields has been developed employing sn-glycero-3-phosphocholine-kieselguhr complex with shorter reaction times with the recycling of kieselguhr for further use. Fatty acids with chain lengths C3–C6 and C8–C18 formed 1,2-diacyl-sn-glycero-3-phosphocholines and 1-acyl-sn-glycero-3-phosphocholines respectively. Fatty acid chlorides (C3–C18) resulted exclusively in 1,2-diacyl-sn-glycero-3-phosphocholines. Practical applications: Synthetic methodology for the synthesis of symmetrical phosphatidylcholines is described. The described method uses kieselguhr as a catalyst and reagent which can be recycled after the reaction. By this method gram quantities of phosphatidylcholines can be prepared without the use of any other acylating reagents. The synthetic method is a novel approach for producing phosphatidylcholines and lysophosphatidylcholines which have wide range of applications. Synthesis of 1-acyl-sn-glycero-3-phosphocholine and 1,2-diacyl-sn-glycero-3-phosphocholine.

中文翻译：

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一种合成1-酰基-sn-甘油-3-磷酸胆碱和1,2-二酰基-sn-甘油-3-磷酸胆碱的新方法

已经开发出一种简便、高效、无溶剂的合成磷酸胆碱和溶血磷酸胆碱的高产率方法，该方法采用 sn-甘油-3-磷酸胆碱-硅藻土复合物，反应时间更短，硅藻土循环利用以进一步使用。链长为 C3-C6 和 C8-C18 的脂肪酸分别形成 1,2-二酰基-sn-甘油-3-磷酸胆碱和 1-酰基-sn-甘油-3-磷酸胆碱。脂肪酸氯化物 (C3–C18) 仅产生 1,2-二酰基-sn-甘油-3-磷酸胆碱。实际应用：描述了合成对称磷脂酰胆碱的合成方法。所述方法使用硅藻土作为催化剂和反应后可循环使用的试剂。通过这种方法，可以在不使用任何其他酰化试剂的情况下制备克量的磷脂酰胆碱。该合成方法是一种生产磷脂酰胆碱和溶血磷脂酰胆碱的新途径，具有广泛的应用前景。1-酰基-sn-甘油-3-磷酸胆碱和1,2-二酰基-sn-甘油-3-磷酸胆碱的合成。