A General Strategy for Development of Activatable NIR-II Fluorescent Probes for in vivo High-Contrast Bioimaging.,Angewandte Chemie International Edition

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A General Strategy for Development of Activatable NIR-II Fluorescent Probes for in vivo High-Contrast Bioimaging.
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2020-09-11 , DOI: 10.1002/anie.202009986
Tian-Bing Ren ₁ , Zhi-Yao Wang ₁ , Zhen Xiang ₁ , Peng Lu ₁ , Huan-Hua Lai ₁ , Lin Yuan ₁ , Xiao-Bing Zhang ₁ , Weihong Tan ₁

Affiliation

Organic dye based NIR‐II fluorescent probes, owing to their high signal‐to‐background ratio and deeper penetration, are highly useful for deep‐tissue high‐contrast imaging in vivo. However, it is still a challenge to design activatable NIR‐II fluorescent probes. Here, a novel class of polymethine dyes (NIRII‐RTs), with bright (quantum yield up to 2.03 %), stable, and anti‐solvent quenching NIR‐II emission, together with large Stokes shifts, was designed. Significantly, the novel NIR‐II dyes NIRII‐RT3 and NIRII‐RT4, equipped with a carboxylic acid group, can serve as effective NIR‐II platforms for the design of activatable bioimaging probes with high contrast. As a proof of concept, a series of target‐activatable NIRII‐RT probes (NIRII‐RT‐pH, NIRII‐RT‐ATP and NIRII‐RT‐Hg) for pH, adenosine triphosphate (ATP), and metal‐ion detection, were synthesized. By applying the NIRII‐RT probe, the real‐time monitoring of drug‐induced hepatotoxicity was realized.

中文翻译：

开发用于体内高对比度生物成像的可激活NIR-II荧光探针的一般策略。

基于有机染料的NIR-II荧光探针由于其高的信噪比和更深的穿透力，对于体内深层组织高对比度成像非常有用。但是，设计可激活的NIR-II荧光探针仍然是一个挑战。在这里，设计了一类新颖的聚次甲基染料（NIRII-RTs），它具有明亮的（量子产率高达2.03％），稳定的抗溶剂猝灭性NIR-II发射以及较大的斯托克斯频移。值得注意的是，配备有羧酸基团的新型NIR-II染料NIRII-RT3和NIRII-RT4可作为有效的NIR-II平台，用于设计具有高对比度的可激活生物成像探针。作为概念验证，一系列用于pH值，三磷酸腺苷（ATP）和金属离子检测的可激活靶标的NIRII-RT探针（NIRII-RT-pH，NIRII-RT-ATP和NIRII-RT-Hg）被合成。通过使用NIRII‐RT探针，可以实现药物诱导的肝毒性的实时监控。

更新日期：2020-09-11

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