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Improved Synthesis of 1H-Pyrazole-4-carbaldehyde
Synthetic Communications ( IF 1.8 ) Pub Date : 2011-08-15 , DOI: 10.1080/00397911.2010.503002
Ilya V. Taydakov , Sergey S. Krasnoselskiy , Tatiana Y. Dutova

Abstract A simple and convenient two-step method for the synthesis of the title compound 1 was developed using N-protected 4-pyrazolilmagnesium bromide 9 as a key intermediate. Laborious procedures for purification or isolation of target compound are not required, therefore, up to 20 g of 1 could be obtained in a single run.

中文翻译:

1H-吡唑-4-甲醛的改进合成

摘要 以N-保护的4-吡唑啉溴化镁9为关键中间体,建立了一种简单方便的两步法合成标题化合物1。不需要用于纯化或分离目标化合物的繁琐程序,因此,单次运行可得到多达 20 g 的 1。
更新日期:2011-08-15
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