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One-Pot Synthesis ofN2-Substituted 2-Amino-4-aryl-5,6,7,8-tetrahydroquinoline-3-carbonitrile in Basic Ionic Liquid [bmim]OH
Synthetic Communications ( IF 1.8 ) Pub Date : 2011-07-11 , DOI: 10.1080/00397911.2010.516459
Yu Wan 1, 2 , Rui Yuan 1 , Fu-Ren Zhang 1 , Li-Ling Pang 1 , Rui Ma 1 , Cai-Hui Yue 1 , Wei Lin 1 , Wei Yin 1 , Rong-Cheng Bo 1 , Hui Wu 1, 2
Affiliation  

Abstract N2-Methyl- or aryl-substituted 2-amino-4-aryl-5,6,7,8-tetrahydroquinoline-3-carbonitriles were synthesized via a four-component, one-pot reaction of aromatic aldehyde, cyclohexanone, malononitrile, and amines in basic ionic liquid [bmim]OH with good to excellent yields. During this transformation, at least 11 bonds were cleaved and 7 new bonds were constructed.

中文翻译:

在碱性离子液体 [bmim] OH 中一锅法合成 N2-取代的 2-氨基-4-芳基-5,6,7,8-四氢喹啉-3-腈

摘要 通过芳醛、环己酮、丙二腈、四组分一锅反应合成了 N2-甲基或芳基取代的 2-氨基-4-芳基-5,6,7,8-四氢喹啉-3-腈类化合物。和胺在碱性离子液体 [bmim] OH 中具有良好的收率。在这个转变过程中,至少有 11 个键被裂解,并构建了 7 个新键。
更新日期:2011-07-11
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