Abstract A series of new alkyl, tosyl, acetyl, and tert-butoxycarbonyl derivatives of 2-(2-aminoethyl)-phthalazinones were efficiently synthesized by reaction of lactams with N-Boc-, N-acetyl-, or N,O-ditosyl derivatives of N-methylethanolamine in the presence of MeONa or under Mitsunobu reaction conditions. Selected compounds were converted into corresponding 2-[2-(methylamino)ethyl]phthalazinones in good yields. GRAPHICAL ABSTRACT

中文翻译：

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2H-Phthalazin-1-ones的N-(2-(甲基氨基)乙基)衍生物的合成

摘要 通过内酰胺与 N-Boc-、N-乙酰基或 N,O-二甲苯基反应，高效合成了一系列 2-(2-氨基乙基)-酞嗪酮的新型烷基、甲苯磺酰基、乙酰基和叔丁氧基羰基衍生物。在 MeONa 存在下或在 Mitsunobu 反应条件下 N-甲基乙醇胺的衍生物。选定的化合物以良好的产率转化为相应的 2-[2-(甲基氨基)乙基]酞嗪酮。图形概要