New synthesis route for the preparation of pomalidomide,Synthetic Communications

当前位置： X-MOL 学术 › Synth. Commun. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

New synthesis route for the preparation of pomalidomide
Synthetic Communications ( IF 1.8 ) Pub Date : 2016-08-03 , DOI: 10.1080/00397911.2016.1189574
Daowei Huang _{1,

2} , Chengwu Shen ₃ , Wenya Wang _{1,

2} , Lei Huang _{1,

2} , Feng Ni _{1,

2} , Jianqi Li _{1,

2}

Affiliation

ABSTRACT A new route for the preparation of pomalidomide is described in the study. The synthetic procedure starts from 4-nitroisobenzofuran-1,3-dione and 3-aminopiperidine-2,6-dione hydrochloride via a three-step reaction resulting in a total yield of 65% with a high-performance liquid chromatographic (HPLC) purity of 99.56% and a low palladium residue level of 2 ppm. This method can be deemed as an efficient, practical, and environmentally friendly synthetic route for the preparation of pomalidomide. GRAPHICAL ABSTRACT

中文翻译：

制备泊马度胺的新合成路线

摘要该研究描述了一种制备泊马度胺的新途径。合成过程从 4-硝基异苯并呋喃-1,3-二酮和 3-氨基哌啶-2,6-二酮盐酸盐开始，经过三步反应，总产率为 65%，具有高效液相色谱 (HPLC) 纯度99.56% 和 2 ppm 的低钯残留水平。该方法是制备泊马度胺的一种高效、实用、环保的合成路线。图形概要

更新日期：2016-08-03

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南