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Synthesis of SMND-309, a derivate of salvianolic acid B
Synthetic Communications ( IF 1.8 ) Pub Date : 2017-06-16 , DOI: 10.1080/00397911.2017.1328602 Kong Wu 1 , Chan Song 1 , Dong-Mei Cui 1 , Chen Zhang 2
Synthetic Communications ( IF 1.8 ) Pub Date : 2017-06-16 , DOI: 10.1080/00397911.2017.1328602 Kong Wu 1 , Chan Song 1 , Dong-Mei Cui 1 , Chen Zhang 2
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ABSTRACT (E)-2-(6-((E)-2-carboxyvinyl)-2,3-dihydroxyphenyl)-3-(3,4-dihydroxyphenyl) acrylic acid, designated SMND-309, was synthesized starting from 2-hydroxy-3-methoxybenzaldehyde in 12 steps and with an overall yield of 44%. The synthetic key features were the conversion of aryl aldehyde into aryl acetic acid for one-carbon extended, the Perkin condensation, and the Heck coupling for construction of α,β-unsaturated ester. GRAPHICAL ABSTRACT
中文翻译：
丹酚酸 B 衍生物 SMND-309 的合成
摘要 (E)-2-(6-((E)-2-羧基乙烯基)-2,3-二羟基苯基)-3-(3,4-二羟基苯基)丙烯酸，命名为 SMND-309，由 2-羟基-3-甲氧基苯甲醛分12步，总收率为44%。合成的关键特征是将芳基醛转化为芳基乙酸以进行一碳扩展、Perkin 缩合和用于构建 α,β-不饱和酯的 Heck 偶联。图形概要
更新日期：2017-06-16
中文翻译：
丹酚酸 B 衍生物 SMND-309 的合成
摘要 (E)-2-(6-((E)-2-羧基乙烯基)-2,3-二羟基苯基)-3-(3,4-二羟基苯基)丙烯酸，命名为 SMND-309，由 2-羟基-3-甲氧基苯甲醛分12步，总收率为44%。合成的关键特征是将芳基醛转化为芳基乙酸以进行一碳扩展、Perkin 缩合和用于构建 α,β-不饱和酯的 Heck 偶联。图形概要
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