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Convenient synthesis of 2-(methylsulfonyl)pyrimidine derivatives
Synthetic Communications ( IF 1.8 ) Pub Date : 2018-02-09 , DOI: 10.1080/00397911.2017.1421664 Tong-Hui Huang 1 , Shan-Shan Zhou 1 , Xin Wu 1 , Lin An 1 , Xiao-Xing Yin 1
Synthetic Communications ( IF 1.8 ) Pub Date : 2018-02-09 , DOI: 10.1080/00397911.2017.1421664 Tong-Hui Huang 1 , Shan-Shan Zhou 1 , Xin Wu 1 , Lin An 1 , Xiao-Xing Yin 1
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ABSTRACT An efficient and convenient approach for the preparation of functionalized 2-(methylsulfonyl)pyrimidine derivatives has been developed through cyclic condensation of malonate derivatives with S-methylisothiouronium sulfate followed by derivation and oxidation in water–acetone mixture using oxone as the oxidant. This synthetic strategy provides an efficient and environmentally friendly approach for easy access to 2-(methylsulfonyl)pyrimidine derivatives with considerable yields. GRAPHICAL ABSTRACT
中文翻译:
2-(甲基磺酰基)嘧啶衍生物的便捷合成
摘要 通过丙二酸衍生物与 S-甲基异硫脲硫酸盐的循环缩合,然后在水-丙酮混合物中使用 oxone 作为氧化剂进行衍生和氧化,开发了一种有效且方便的制备功能化 2-(甲基磺酰基)嘧啶衍生物的方法。这种合成策略提供了一种高效且环保的方法,可以轻松获得具有可观产率的 2-(甲基磺酰基)嘧啶衍生物。图形概要
更新日期:2018-02-09
中文翻译:
2-(甲基磺酰基)嘧啶衍生物的便捷合成
摘要 通过丙二酸衍生物与 S-甲基异硫脲硫酸盐的循环缩合,然后在水-丙酮混合物中使用 oxone 作为氧化剂进行衍生和氧化,开发了一种有效且方便的制备功能化 2-(甲基磺酰基)嘧啶衍生物的方法。这种合成策略提供了一种高效且环保的方法,可以轻松获得具有可观产率的 2-(甲基磺酰基)嘧啶衍生物。图形概要