Abstract 4-Formylphenyl benzoate was utilized as a versatile precursor for the construction of new series of heterocyclic scaffolds that contain thiazole and thiazolidin-5-one rings. The antibacterial activity of these scaffolds against two types of bacteria was screened and most of them exhibited good activity. Among the synthesized thiazole derivatives, compounds 5, 6, and 8a showed antibacterial activity close to the standard chemotherapeutic (Ampicillin). Graphical Abstract

中文翻译：

---

一些含有苯甲酸苯酯部分的新型噻唑和噻唑烷酮衍生物的合成、表征和抗菌活性

摘要 4-甲酰基苯甲酸酯被用作一种通用前体，用于构建包含噻唑和噻唑烷-5-one 环的新系列杂环支架。筛选了这些支架对两种细菌的​​抗菌活性，其中大部分表现出良好的活性。在合成的噻唑衍生物中，化合物 5、6 和 8a 显示出接近标准化疗药物（氨苄青霉素）的抗菌活性。图形概要