Abstract

A highly regioselective ring opening reaction of terminal epoxides with 2-bromobenzoic acid catalyzed by tetrabutylammonium bromide was accomplished. The procedure is operationally simple and practical for the synthesis of a series of β-hydroxy esters. Using this protocol, oxetan-3-ol could be prepared efficiently in a good yield.

中文翻译：

---

Oxetan-3-ol的改良合成

摘要

在四丁基溴化铵的催化下，完成了末端环氧化物与2-溴苯甲酸的高度区域选择性开环反应。该程序操作简单且实用，可用于合成一系列β-羟基酯。使用该方案，可以高效且高收率地制备环氧乙烷-3-醇。