Abstract The reaction of thiophene-2-carbonyl isothiocyanate with phenylhydrazine gave 1-phenyl-5-(thien-2-yl)-1,2,4-triazole-3-thiol which was transformed by follow-up reactions into derivatives substituted in the 3-position by 1,2,4-oxadiazole and 1,2,4-thiadiazole moieties via thioethers linkages. The antitumor activity of the products against two human tumor cell lines, namely hepatocellular carcinoma HePG-2 and mammary gland breast cancer MCF-7 as well as the antimicrobial activity of some of these compounds was evaluated. Graphical Abstract

中文翻译：

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噻吩-2-羰基异硫氰酸酯作为合成 1,2,4-三唑、1,3,4-恶二唑和 1,3,4-噻二唑衍生物的前体的效用及其抗肿瘤和抗菌活性的评价

摘要 噻吩-2-羰基异硫氰酸酯与苯肼反应生成 1-苯基-5-(噻吩-2-基)-1,2,4-三唑-3-硫醇，通过后续反应转化为1,2,4-恶二唑和 1,2,4-噻二唑部分通过硫醚键连接到 3-位。评估了产品对两种人类肿瘤细胞系，即肝细胞癌 HePG-2 和乳腺乳腺癌 MCF-7 的抗肿瘤活性以及其中一些化合物的抗微生物活性。图形概要