Abstract

A series of chalcone derivatives containing quinoxaline moieties were synthesized, and their antibacterial activities were evaluated. Antibacterial bioassays indicated that some of the compounds exhibited significant antibacterial activity against Xanthomonas axonopodis pv. Citri (Xac), Xanthomonas oryzae pv. oryzae (Xoo), and Ralstonia solanacearum (Rs) at the concentrations of 50 or 100 μg/cm³. 50% effective concentration (EC₅₀) values of (E)-3-(pyridin-2-yl)-1-[4-(quinoxalin-2-yloxy)phenyl]prop-2-en-1-one against Xac, Xoo, and Rs were 6.72, 15.17, and 9.29 μg/cm³, respectively, which were better than those of bismerthiazol (44.31, 42.46, and 62.36 μg/cm³, respectively). Scanning electron microscopy (SEM) was employed to analyze the mechanism of antibacterial action of that compound toward Xac.

Graphical abstract

中文翻译：

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含喹喔啉部分查尔酮衍生物的抗菌评价及作用机理

摘要

合成了一系列包含喹喔啉部分的查尔酮衍生物，并评估了它们的抗菌活性。抗菌生物测定结果表明，某些化合物对轴生黄单胞菌pv表现出显着的抗菌活性。柑桔（Xac），黄单胞菌（Xanthomonas oryzae）PV。浓度为50或100μg/ cm ^3的稻米（Xoo）和青枯雷尔氏菌（Rsstonia solanacearum）（Rs）。（E）-3-（吡啶-2-基）-1- [4-（喹喔啉-2-基氧基）苯基] prop-2-en-1-one对Xac的50％有效浓度（EC ₅₀）值， Xoo和Rs分别为6.72、15.17和9.29μg / cm ³，比bismerthiazol（44.31、42.46和62.36μg / cm）更好。³）。使用扫描电子显微镜（SEM）分析该化合物对Xac的抗菌作用机理。

图形概要