5‐(Aminomethyl)‐2‐furanmethanol (AMF), used widely in medicinal chemistry, is usually synthesized by the reductive amination of furfural or 5‐hydroxymethylfurfural (HMF) with ammonia. However, a challenging task when synthesizing this furyl primary amine is to enhance the selectivity of the product due to its high nucleophilicity. Conventional measures have used excessive liquid ammonia and precious metal catalysts. Usually, the molar ratio of ammonia to substrate is up to 30:1. This study employed aqueous ammonia to synthesize AMF by the direct reductive amination of HMF using the non‐noble metal Ni/SBA‐15 catalyst.

中文翻译：

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通过在Ni / SBA-15催化剂上用氨水直接还原5-羟甲基糠醛与氨合制备5（氨基甲基）-2-呋喃甲醇

5-（氨基甲基）-2-呋喃甲醇（AMF）在药物化学中广泛使用，通常通过糠醛或5-羟甲基糠醛（HMF）与氨的还原胺化反应合成。然而，合成该呋喃基伯胺时的一项艰巨任务是由于其高亲核性而提高产物的选择性。常规措施使用过量的液态氨和贵金属催化剂。通常，氨与底物的摩尔比高达30：1。这项研究使用氨水通过使用非贵金属Ni / SBA-15催化剂对HMF进行直接还原胺化来合成AMF。