Aspirin (abbr. ASA) is intercalated into the layered terbium hydroxide (LTbH) by anion exchange method. Structure, chemical compositions, thermostability, morphology, luminescence property, cytotoxic effects and controlled‐release behaviors have been investigated. The ASA molecules may embed between layers with monolayered vertical arrangement, and the thermal stability of organics was enhanced after intercalation. The Tb³⁺ luminescence in ASA‐LTbH composites was enhanced compared with LTbH precusor and the luminescence intensity increased with the deprotonation degree. The cytotoxic effect of LTbH was observed with a sulforhodamine B (SRB) colorimetric assay, which revealed that the LTbH showed low cytotoxic effects. In addition, the ASA‐LTbH composites exhibited a sustained release of ASA in Na₂HPO₄‐NaH₂PO₄ buffer solution at pH 6.86 and 37°C. Construction of LRHs composites with drug molecules provided a beneficial pathway for preparing biohybrid based on LRHs, which may have potential applications in drug delivery carrier and biological fluorescence probe.

中文翻译：

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基于层状氢氧化ter的生物混合物及其在药物载体和生物荧光探针中的应用

通过阴离子交换法将阿司匹林（缩写为ASA）插入层状氢氧化ter（LTbH）中。研究了结构，化学组成，热稳定性，形态，发光特性，细胞毒性作用和控释行为。ASA分子可以以单层垂直排列嵌入层之间，并且插层后有机物的热稳定性得到增强。与LTbH先驱者相比，ASA-LTbH复合材料中的Tb ³⁺发光增强，并且发光强度随去质子度而增加。用磺基罗丹明B（SRB）比色法观察到LTbH的细胞毒性作用，这表明LTbH显示出低的细胞毒性作用。此外，ASA-LTbH复合材料在Na _2中表现出ASA的持续释放pH 6.86和37°C下的HPO _4- NaH ₂ PO ₄缓冲溶液。具有药物分子的LRHs复合物的构建为制备基于LRHs的生物杂化物提供了有益的途径，可能在药物递送载体和生物荧光探针中具有潜在的应用前景。