Three novel copper(II) complexes, [Cu(Gly‐l‐Val)(HPBM)(H₂O)]·ClO₄·H₂O (1), [Cu(Gly‐l‐Val)(TBZ)(H₂O)]·ClO₄ (2) and [Cu(Gly‐l‐Val)(PBO)(H₂O)]·ClO₄ (3) (Gly‐l‐Val = glycyl‐l‐valine anion, HPBM = 5‐methyl‐2‐(2′‐pyridyl)benzimidazole, TBZ = 2‐(4′‐thiazolyl)benzimidazole, PBO = 2‐(2′‐pyridyl)benzoxazole), have been prepared and characterized with elemental analyses, conductivity measurements as well as various spectroscopic techniques. The interactions of these copper complexes with calf thymus DNA were explored using UV–visible, fluorescence, circular dichroism, thermal denaturation, viscosity and docking analyses methods. The experimental results showed that all three complexes could bind to DNA via an intercalative mode. Moreover, the cytotoxic effects were evaluated using the MTT method, and the antimicrobial activity of these complexes was tested against Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. The results showed that the activities are consistent with their DNA binding abilities, following the order of 1 > 2 > 3.

中文翻译：

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三种新的含配位基-1-缬氨酸和N，N-芳族杂环化合物的混合配体铜（II）配合物：合成，表征，DNA相互作用，细胞毒性和抗菌活性

三种新型铜（II）配合物，[Cu（上Gly-升-Val）（HPBM）（H ₂ O）]·CLO ₄ ·H ₂ O（1），[Cu（上Gly-升-Val）（TBZ）（ H ₂ O）]·ClO ₄（2）和[Cu（Glyl - Val）（PBO）（H ₂ O）]·ClO ₄（3）（Glyl - Val =甘氨酰l已制备了缬氨酸阴离子，HPBM = 5-甲基-2-（2'-吡啶基）苯并咪唑，TBZ = 2-（4'-噻唑基）苯并咪唑，PBO = 2-（2'-吡啶基）苯并恶唑）进行元素分析，电导率测量以及各种光谱技术。使用紫外可见光，荧光，圆二色性，热变性，粘度和对接分析方法探索了这些铜络合物与小牛胸腺DNA的相互作用。实验结果表明，所有三种复合物都可以通过插入模式与DNA结合。此外，使用MTT方法评估了细胞毒性作用，并测试了这些复合物对枯草芽孢杆菌，金黄色葡萄球菌，大肠杆菌和大肠杆菌的抗菌活性。铜绿假单胞菌。结果表明，活性与其DNA结合能力一致，顺序为1 > 2 > 3。