无标签的荧光中孔生物玻璃，用于药物输送，光学三模式成像和光热/光动力协同癌症治疗,ACS Applied Bio Materials

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无标签的荧光中孔生物玻璃，用于药物输送，光学三模式成像和光热/光动力协同癌症治疗
ACS Applied Bio Materials ( IF 4.6 ) Pub Date : 2020-03-02 00:00:00 , DOI: 10.1021/acsabm.0c00050
Rajendra K. Singh _{1,

2} , Amal George Kurian _{1,

2} , Kapil D. Patel _{1,

2,

3} , Nandin Mandakhbayar _{1,

2} , Na-Hyun Lee _{1,

2} , Jonathan C. Knowles _{2,

3,

4} , Jung-Hwan Lee _{1,

2,

4,

5} , Hae-Won Kim _{1,

2,

4,

5}

Affiliation

纳米材料与光疗和多峰成像相结合有望用于癌症治疗学。我们的目标是开发基于碳点（CD）的荧光介孔生物玻璃纳米颗粒（fBGn），并具有用于癌症治疗的传递，三模式成像和光热（PTT）特性。使用直接且无标签的方法，以3-氨基丙基三乙氧基硅烷为表面官能化剂，制备了多色荧光fBGn。在400°C下煅烧可为fBGn提供源自CD的高荧光强度。尤其是，观察到三态发射[荧光成像，双光子（TP）和拉曼成像]，这取决于CD性质和表面特性，例如表面氧化边缘状态，非晶区，表面状态的氮钝化和结晶区域。fBGn还表现出光疗特性，例如光动力（PDT）和PTT效应。PDT / PTT联合治疗的抗肿瘤作用明显高于单个（PDT或PTT）治疗。fBGn由于具有介孔结构，因此可以以pH依赖的方式加载和释放抗癌药阿霉素，从而显示出对癌细胞的化疗作用。fBGn的体内成像和生物相容性也在裸鼠模型中得到证明。fBGn具有抗癌递送，三重模式成像和PTT / PDT治疗的综合能力，被认为可能对癌症治疗学有用。由于具有介孔结构，可以以pH依赖的方式加载和释放抗癌药阿霉素，从而显示出对癌细胞的化疗作用。fBGn的体内成像和生物相容性也在裸鼠模型中得到证明。fBGn具有抗癌递送，三重模式成像和PTT / PDT治疗的综合能力，被认为可能对癌症治疗学有用。由于具有介孔结构，可以以pH依赖的方式加载和释放抗癌药阿霉素，从而显示出对癌细胞的化疗作用。fBGn的体内成像和生物相容性也在裸鼠模型中得到证明。fBGn具有抗癌递送，三重模式成像和PTT / PDT治疗的综合能力，被认为可能对癌症治疗学有用。

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Label-Free Fluorescent Mesoporous Bioglass for Drug Delivery, Optical Triple-Mode Imaging, and Photothermal/Photodynamic Synergistic Cancer Therapy

Nanomaterials combined with phototherapy and multimodal imaging are promising for cancer theranostics. Our aim is to develop fluorescent mesoporous bioglass nanoparticles (fBGn) based on carbon dots (CD) with delivery, triple-mode imaging, and photothermal (PTT) properties for cancer theranostics. A direct and label-free approach was used to prepare multicolor fluorescent fBGn with 3-aminopropyl triethoxysilane as the surface-functionalizing agent. The calcination at 400 °C provided fBGn with high fluorescence intensity originating from the CD. In particular, a triple-mode emission [fluorescence imaging, two-photon (TP), and Raman imaging] was observed which depended on CD nature and surface properties such as surface oxidation edge state, amorphous region, nitrogen passivation of surface state, and crystalline region. The fBGn also exhibited phototherapeutic properties such as photodynamic (PDT) and PTT effects. The antitumor effect of the combined PDT/PTT therapy was significantly higher than that of individual (PDT or PTT) therapy. The fBGn, due to the mesoporous structure, the anticancer drug doxorubicin could be loaded and released in a pH-dependent way to show chemotherapy effects on cancer cells. The in vivo imaging and biocompatibility of fBGn were also demonstrated in a nude mouse model. The fBGn, with the combined capacity of anticancer delivery, triple-mode imaging, and PTT/PDT therapy, are considered to be potentially useful for cancer theranostics.

更新日期：2020-03-02

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