Selective photoredox decarboxylation of α-ketoacids to allylic ketones and 1,4-dicarbonyl compounds dependent on cobaloxime catalysis.,Chemical Communications

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Selective photoredox decarboxylation of α-ketoacids to allylic ketones and 1,4-dicarbonyl compounds dependent on cobaloxime catalysis.
Chemical Communications ( IF 4.3 ) Pub Date : 2020-09-11 , DOI: 10.1039/d0cc05580h
Hong Zhang ₁ , Qian Xiao ₁ , Xu-Kuan Qi ₁ , Xue-Wang Gao ₂ , Qing-Xiao Tong ₁ , Jian-Ji Zhong ₁

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A photoredox/cobaloxime co-catalyzed coupling reaction of α-ketoacids and methacrylates to obtain allylic ketones is described. Without the cobaloxime catalyst, 1,4-dicarbonyl compounds are generated. The cobaloxime catalyst enables dehydrogenation to generate the formation of new olefins. The generality, good substrate scope and mild conditions are good features in the photoredox/cobaloxime catalysis protocol, and this method will provide new opportunities for the functionalization of more olefins.

中文翻译：

α-酮酸选择性光氧化还原脱羧为烯丙基酮和1,4-二羰基化合物，取决于钴肟的催化作用。

描述了光氧化还原/钴肟共催化的α-酮酸和甲基丙烯酸酯的偶联反应，以获得烯丙基酮。如果没有钴肟肟催化剂，则会生成1,4-二羰基化合物。该钴肟肟催化剂能够脱氢以生成新的烯烃。通用性，良好的底物范围和温和的条件是光氧化还原/钴氧肟催化方案的良好特征，该方法将为更多烯烃的功能化提供新的机会。

更新日期：2020-10-20

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