A Janus Hydrogel Wet Adhesive for Internal Tissue Repair and Anti‐Postoperative Adhesion,Advanced Functional Materials

当前位置： X-MOL 学术 › Adv. Funct. Mater. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

A Janus Hydrogel Wet Adhesive for Internal Tissue Repair and Anti‐Postoperative Adhesion
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2020-09-11 , DOI: 10.1002/adfm.202005689
Chunyan Cui ₁ , Tengling Wu ₁ , Xinyu Chen ₁ , Yang Liu ₁ , Yuan Li ₁ , Ziyang Xu ₁ , Chuanchuan Fan ₁ , Wenguang Liu ₁

Affiliation

Despite rapid development of adhesive hydrogels, the typical double‐sided adhesives fail to adhere to wet tissues and concurrently prevent postoperative tissue adhesion, thus severely limiting their applications in repair of internal tissues. Herein, a negatively charged carboxyl‐containing hydrogel is gradiently, electrostatically complexed with a cationic oligosaccharide by a one‐sided dipping method to form a novel Janus hydrogel wet adhesive whose two‐side faces demonstrate strikingly distinct adhesive and nonadhesive properties. The lightly complexed surface demonstrates instant robust adhesion to various wet biological tissues even under water since the phase separation induced by electrostatic complexation increases the hydrophobicity and water drainage capacity. Intriguingly, the highly complexed surface is non‐adhesive due to complete neutralization of carboxyls in the hydrogels. The Janus hydrogel can be used to replace traditional sutures to treat gastric perforation of rabbits. Animal experiment outcomes reveal that one side of the Janus hydrogel is firmly glued to the stomach tissue, and other side facing outward can efficiently prevent the postoperative adhesion. Molecular simulation elucidates the importance for selecting cationic polymer species. It is believed that gradient polyelectrolyte complexation establish a new direction to create Janus adhesives for internal tissue/organ repair and simultaneous prevention of post‐operative adhesion.

中文翻译：

Janus水凝胶湿胶，用于内部组织修复和抗术后粘连

尽管粘性水凝胶发展迅速，但典型的双面粘合剂无法粘附在湿的组织上，并不能阻止术后组织的粘附，从而严重限制了它们在修复内部组织中的应用。在本文中，通过单侧浸涂法将带负电荷的含羧基水凝胶与阳离子寡糖进行梯度静电复合，以形成新颖的Janus水凝胶湿粘合剂，其双面均具有显着不同的粘合和非粘合特性。由于静电络合引起的相分离增加了疏水性和排水能力，因此轻度络合的表面即使在水下也表现出对各种湿生物组织的即时牢固粘附。有趣的是由于水凝胶中的羧基完全被中和，因此高度复杂的表面是非粘性的。Janus水凝胶可用于替代传统的缝合线，以治疗兔子的胃穿孔。动物实验结果表明，Janus水凝胶的一侧牢固地粘在胃组织上，而另一侧朝外可以有效地防止术后粘连。分子模拟阐明了选择阳离子聚合物种类的重要性。人们认为，梯度聚电解质络合物为创建Janus粘合剂以进行内部组织/器官修复和同时预防术后粘连建立了新的方向。动物实验结果表明，Janus水凝胶的一侧牢固地粘在胃组织上，而另一侧朝外可以有效地防止术后粘连。分子模拟阐明了选择阳离子聚合物种类的重要性。人们认为，梯度聚电解质络合物为创建Janus粘合剂以进行内部组织/器官修复和同时预防术后粘连建立了新的方向。动物实验结果表明，Janus水凝胶的一侧牢固地粘在胃组织上，而另一侧朝外可以有效地防止术后粘连。分子模拟阐明了选择阳离子聚合物种类的重要性。人们认为，梯度聚电解质络合物为创建Janus粘合剂以进行内部组织/器官修复和同时预防术后粘连建立了新的方向。

更新日期：2020-09-11

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南