2,6-二氨基吡啶和丙烯酰胺基共聚物，在水溶液中具有较高的临界溶液温度类型行为,Journal of Polymer Science

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2,6-二氨基吡啶和丙烯酰胺基共聚物，在水溶液中具有较高的临界溶液温度类型行为
Journal of Polymer Science ( IF 3.9 ) Pub Date : 2019-08-26 , DOI: 10.1002/pola.29474
Asad Asadujjaman _{1,

2} , Vahid Ahmadi _{1,

3} , Antoine Michel Claude Franc ₁ , Annabelle Bertin _{1,

3}

Affiliation

基于超分子基序2,6-二氨基吡啶和水溶性丙烯酰胺，聚[甲新型共聚物ñ - （6- acetamidopyridin -2-基）丙烯酰胺共[丙烯酰胺]，是通过可逆的加成-断裂链转移（RAFT）聚合与各种单体组成合成的。通过比浊法和动态光散射（DLS）研究了共聚物的热响应性能。所得共聚物在水和电解质溶液中显示出较高的临界溶液温度（UCST）型相变行为。发现相转变温度随着共聚物中丙烯酰胺的减少和溶液浓度的增加而增加。此外，根据Hoffmeister系列，在电解质水溶液中的相变温度根据电解质的性质和浓度而变化。在这项研究中观察到了显着的溶剂同位素对转变温度的影响，₂ O比在相同浓度的H ₂ O和丙烯酰胺组成。在D ₂ O中，转变温度以下的聚集体的尺寸大于在H ₂ O中的聚集体的尺寸，这可以用氘同位素效应来解释。还研究了共聚物在不同细胞培养基中的热响应行为，发现在不同细胞培养基中表现出UCST型相变行为。共聚物的这种行为可用于许多应用中，包括生物医学，微流体，光学材料以及药物递送。©2019 Wiley Periodicals，Inc.J.Polym。科学，A部分：Polym。化学 2019，57，2064–2073

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2,6‐Diaminopyridine and Acrylamide‐Based Copolymers with Upper Critical Solution Temperature‐type Behavior in Aqueous Solution

A novel copolymer based on supramolecular motif 2,6‐diaminopyridine and water‐soluble acrylamide, poly[N‐(6‐acetamidopyridin‐2‐yl) acrylamide‐co‐acrylamide], was synthesized via reversible addition–fragmentation chain transfer (RAFT) polymerization with various monomer compositions. The thermoresponsive behavior of the copolymers was studied by turbidimetry and dynamic light scattering (DLS). The obtained copolymers showed an upper critical solution temperature (UCST)‐type phase transition behavior in water and electrolyte solution. The phase transition temperature was found to increase with decreasing amount of acrylamide in the copolymer and increasing concentration of the solution. Furthermore, the phase transition temperature varied in aqueous solutions of electrolytes according to the nature and concentration of the electrolyte in accordance with the Hoffmeister series. A dramatic solvent isotope effect on the transition temperature was observed in this study, as the transition temperature was almost 10–12 °C higher in D₂O than in H₂O at the same concentration and acrylamide composition. The size of the aggregates below the transition temperature was larger in D₂O compared to that in H₂O that can be explained by deuterium isotope effect. The thermoresponsive behavior of the copolymers was also investigated in different cell medium and found to be exhibited UCST‐type phase transition behavior in different cell medium. Such behavior of the copolymers can be useful in many applications including biomedical, microfluidics, optical materials, and in drug delivery. © 2019 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2019, 57, 2064–2073

更新日期：2019-08-26

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