Facile Fabrication of Biocompatible Gelatin-Based Self-Healing Hydrogels,ACS Applied Energy Materials

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Facile Fabrication of Biocompatible Gelatin-Based Self-Healing Hydrogels
ACS Applied Energy Materials ( IF 5.4 ) Pub Date : 2019-04-24 00:00:00 , DOI: 10.1021/acsapm.9b00143
Jinfeng Lei ₁ , Xinying Li ₂ , Shen Wang ₁ , Lun Yuan ₁ , Liming Ge ₁ , Defu Li ₁ , Changdao Mu ₁

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The self-healing hydrogels are extremely attractive in biological and biomedical fields. The imine bond obtained by the Schiff base reaction is a commonly used dynamic covalent bond to fabricate self-healing hydrogels. Gelatin is a commonly used natural macromolecule in the biomedical field with excellent biocompatibility, biodegradability, and nonimmunogenicity. However, the gelatin-based hydrogels with self-healing ability are rarely reported based on imine bonds. Herein, we present a facile approach to fabricate a gelatin hydrogel with self-healing ability based on the Schiff base reaction. The gelatin was first reacted with ethylenediamine to increase the content of amino groups. Then dialdehyde carboxymethyl cellulose was used to cross-link amino-gelatin to fabricate the self-healing hydrogel. The results showed that the fabricated hydrogel exhibited good self-healing ability as expected because of the formed dynamic imine bonds between amino-gelatin and dialdehyde carboxymethyl cellulose. The hydrogel also presented good fatigue resistance and self-recovery capacity. Moreover, the self-healing hydrogel possessed ideal hemocompatibility and cytocompatibility. In sum, the fabricated self-healing hydrogel has application prospects in biomedical fields, such as injectable cell and drug carrier and injectable tissue engineering scaffold.

中文翻译：

基于生物相容性明胶的自愈水凝胶的简便制备

自修复水凝胶在生物和生物医学领域极具吸引力。通过席夫碱反应获得的亚胺键是制备自修复水凝胶的常用动态共价键。明胶是生物医学领域中常用的天然大分子，具有出色的生物相容性，生物降解性和非免疫原性。然而，很少有基于亚胺键的具有自愈能力的基于明胶的水凝胶。本文中，我们提出了一种基于席夫碱反应制备具有自愈能力的明胶水凝胶的简便方法。首先使明胶与乙二胺反应以增加氨基含量。然后，使用二醛羧甲基纤维素使氨基明胶交联以制备自愈水凝胶。结果表明，由于氨基明胶与二醛羧甲基纤维素之间形成了动态亚胺键，所制得的水凝胶表现出了良好的自我修复能力。该水凝胶还表现出良好的抗疲劳性和自恢复能力。而且，自愈水凝胶具有理想的血液相容性和细胞相容性。综上所述，所制备的自愈水凝胶在生物医学领域具有应用前景，例如可注射的细胞和药物载体以及可注射的组织工程支架。自愈水凝胶具有理想的血液相容性和细胞相容性。综上所述，所制备的自愈水凝胶在生物医学领域具有应用前景，例如可注射的细胞和药物载体以及可注射的组织工程支架。自愈水凝胶具有理想的血液相容性和细胞相容性。综上所述，所制备的自愈水凝胶在生物医学领域具有应用前景，例如可注射的细胞和药物载体以及可注射的组织工程支架。

更新日期：2019-04-24

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