CuI/2-Aminopyridine 1-Oxide Catalyzed Amination of Aryl Chlorides with Aliphatic Amines.,Organic Letters

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CuI/2-Aminopyridine 1-Oxide Catalyzed Amination of Aryl Chlorides with Aliphatic Amines.
Organic Letters ( IF 4.9 ) Pub Date : 2020-09-10 , DOI: 10.1021/acs.orglett.0c02672
Wenjie Liu ₁ , Jiamin Xu ₁ , Xiahong Chen ₁ , Fuxing Zhang ₁ , Zhifeng Xu ₁ , Deping Wang ₁ , Yongqiang He ₂ , Xiaohong Xia ₂ , Xin Zhang _{1,

3} , Yun Liang ₃

Affiliation

A class of 2-aminopyridine 1-oxides are discovered to be effective ligands for the Cu-catalyzed amination of less reactive (hetero)aryl chlorides. A wide range of functionalized (hetero)aryl chlorides reacted with various aliphatic amines to afford the desired products in good to excellent yields under the catalyst of CuI/2-aminopyridine 1-oxides. Furthermore, the catalyst system worked well for the coupling of cyclic secondary amines and N-methyl benzylamine with (hetero)aryl chlorides.

中文翻译：

CuI / 2-氨基吡啶-1-氧化物催化脂肪族胺与芳基氯化物的胺化反应。

发现一类2-氨基吡啶1-氧化物是用于铜反应性较低的（杂）芳基氯化物的铜催化胺化的有效配体。在CuI / 2-氨基吡啶1-氧化物的催化剂下，各种官能化的（杂）芳基氯化物与各种脂族胺反应，以良好或优异的收率提供所需的产物。此外，该催化剂体系对于环状仲胺和N-甲基苄基胺与（杂）芳基氯化物的偶联作用良好。

更新日期：2020-10-02

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