<br>传递体：一种有前途的透皮药物递送纳米封装技术。,Pharmaceutics

当前位置： X-MOL 学术 › Pharmaceutics › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

传递体：一种有前途的透皮药物递送纳米封装技术。
Pharmaceutics ( IF 4.9 ) Pub Date : 2020-09-09 , DOI: 10.3390/pharmaceutics12090855
Shakthi Apsara Thejani Opatha ₁ , Varin Titapiwatanakun ₁ , Romchat Chutoprapat ₁

Affiliation

近年来，透皮递送系统由于其与传统口服和肠胃外递送系统相比的优点而引起了广泛关注。它们是非侵入性和自我管理的输送系统，可以提高患者的依从性并提供治疗药物的受控释放。透皮给药系统的最大挑战是皮肤最外层的屏障功能。分子量大于 500 Da 的分子和离子化化合物通常不会穿过皮肤。因此，只有有限数量的药物能够通过这种途径给药。将药物封装在传递体中是克服这一问题的潜在方法之一。它们具有双层结构，有利于亲脂性、亲水性以及两亲性药物的封装，与传统脂质体相比，具有更高的渗透效率。传递体本质上是有弹性的，它可以变形并通过比其尺寸小得多的狭窄孔将自己挤压成完整的囊泡。本综述旨在描述传递体的概念、作用机制、不同的制备方法和表征以及影响传递体特性的因素，以及它们在透皮给药方面的最新应用。

"点击查看英文标题和摘要"

Transfersomes: A Promising Nanoencapsulation Technique for Transdermal Drug Delivery.

Transdermal delivery systems have gained much interest in recent years owing to their advantages compared to conventional oral and parenteral delivery systems. They are noninvasive and self-administered delivery systems that can improve patient compliance and provide a controlled release of the therapeutic agents. The greatest challenge of transdermal delivery systems is the barrier function of the skin’s outermost layer. Molecules with molecular weights greater than 500 Da and ionized compounds generally do not pass through the skin. Therefore, only a limited number of drugs are capable of being administered by this route. Encapsulating the drugs in transfersomes are one of the potential approaches to overcome this problem. They have a bilayered structure that facilitates the encapsulation of lipophilic and hydrophilic, as well as amphiphilic, drug with higher permeation efficiencies compared to conventional liposomes. Transfersomes are elastic in nature, which can deform and squeeze themselves as an intact vesicle through narrow pores that are significantly smaller than its size. This review aims to describe the concept of transfersomes, the mechanism of action, different methods of preparation and characterization and factors affecting the properties of transfersomes, along with their recent applications in the transdermal administration of drugs.

更新日期：2020-09-10

点击分享查看原文

点击收藏

公开下载

阅读更多本刊新发论文本刊介绍/投稿指南