The physicochemical properties of drugs and drug–additive interactions have great importance to elucidate the pharmacological effect of the drug formulations. Plentiful pharmacologically active molecules are amphiphilic in nature. Knowledge about self-assembly, aggregate morphology as well as size and interfacial/micellar properties of such drugs in presence of pharmaceutical excipients (surfactants, electrolytes, polymers, hydrotropes, etc.) is vital from the fundamental and practical point of view. This article reviews the micellar properties and phase separation of drugs as well as drug–additive systems in aqueous and organic solvent–water mixed media. Results of several pharmaceutical excipients/surfactants assisted drug mixed systems have been analyzed through thermodynamic parameters which provide a comprehensive account on the physicochemical aspects of drug/drug–additives systems. Along with amphiphilic drugs, studies of a few non surface-active drugs have also been reviewed.

药物的理化性质和药物与药物的相互作用对于阐明药物制剂的药理作用非常重要。大量的药理活性分子本质上是两亲的。从基础和实践的观点出发，关于在药物赋形剂（表面活性剂，电解质，聚合物，水溶助长剂等）存在下此类药物的自组装，聚集体形态以及尺寸和界面/胶束性质的知识至关重要。本文回顾了水性和有机溶剂-水混合介质中药物以及药物-添加剂系统的胶束特性和相分离。通过热力学参数分析了几种药物赋形剂/表面活性剂辅助药物混合系统的结果，这些参数对药物/药物-添加剂系统的物理化学方面提供了全面的说明。除两亲药物外，还对一些非表面活性药物的研究进行了综述。