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Preparation of antibacterial biocompatible polycaprolactone/keratin nanofibrous mats by electrospinning
Journal of Applied Polymer Science ( IF 2.7 ) Pub Date : 2020-09-07 , DOI: 10.1002/app.49862 Yang Wang 1 , Yingfeng Wang 1 , Lin Li 1 , Yan Zhang 1 , Xuehong Ren 1
Journal of Applied Polymer Science ( IF 2.7 ) Pub Date : 2020-09-07 , DOI: 10.1002/app.49862 Yang Wang 1 , Yingfeng Wang 1 , Lin Li 1 , Yan Zhang 1 , Xuehong Ren 1
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Keratin‐based materials are widely used in biomedical applications due to excellent biocompatibility and biodegradability. In this study, keratin was extracted from waste wool fibers and blended with polycaprolactone (PCL) to produce PCL/keratin nanofibrous mats by electrospinning. The electrospun PCL/keratin nanofibrous mats were chlorinated in diluted sodium hypochlorite solution to endow antibacterial properties. The prepared nanofibrous mats were characterized by scanning electron microscopy, X‐ray photoelectron, and Fourier infrared spectroscopy. The effect of the chlorination time on the active chlorine loading of the mats was investigated. The chlorinated PCL/keratin nanofibrous mats with 0.78 ± 0.009 wt% active chlorine displayed potent antibacterial activity against Gram‐positive Staphylococcus aureus (ATCC 6538) and Gram‐negative Escherichia coli O157:H7 (ATCC 43895) with 6.88 and 6.81 log reductions, respectively. It was found that the mats were compatible with mouse fibroblast cells (L929). The chlorinated PCL/keratin nanofibrous mats might find promising applications in the biomedical field.
中文翻译：
静电纺丝制备抗菌生物相容性聚己内酯/角蛋白纳米纤维垫
基于角蛋白的材料因其出色的生物相容性和生物降解性而广泛用于生物医学应用。在这项研究中，从废羊毛纤维中提取角蛋白，并与聚己内酯（PCL）混合，通过静电纺丝生产PCL /角蛋白纳米纤维垫。将静电纺丝的PCL /角蛋白纳米纤维垫在稀释的次氯酸钠溶液中氯化，以赋予抗菌性能。通过扫描电子显微镜，X射线光电子和傅立叶红外光谱对制备的纳米纤维毡进行表征。研究了氯化时间对垫子活性氯负荷的影响。活性氯为0.78±0.009 wt％的氯化PCL /角蛋白纳米纤维垫对革兰氏阳性金黄色葡萄球菌显示出有效的抗菌活性（ATCC 6538）和革兰氏阴性大肠杆菌O157：H7（ATCC 43895）分别减少了6.88和6.81对数。发现垫子与小鼠成纤维细胞兼容（L929）。氯化PCL /角蛋白纳米纤维垫在生物医学领域可能会找到有希望的应用。
更新日期：2020-11-12
中文翻译：
静电纺丝制备抗菌生物相容性聚己内酯/角蛋白纳米纤维垫
基于角蛋白的材料因其出色的生物相容性和生物降解性而广泛用于生物医学应用。在这项研究中，从废羊毛纤维中提取角蛋白，并与聚己内酯（PCL）混合，通过静电纺丝生产PCL /角蛋白纳米纤维垫。将静电纺丝的PCL /角蛋白纳米纤维垫在稀释的次氯酸钠溶液中氯化，以赋予抗菌性能。通过扫描电子显微镜，X射线光电子和傅立叶红外光谱对制备的纳米纤维毡进行表征。研究了氯化时间对垫子活性氯负荷的影响。活性氯为0.78±0.009 wt％的氯化PCL /角蛋白纳米纤维垫对革兰氏阳性金黄色葡萄球菌显示出有效的抗菌活性（ATCC 6538）和革兰氏阴性大肠杆菌O157：H7（ATCC 43895）分别减少了6.88和6.81对数。发现垫子与小鼠成纤维细胞兼容（L929）。氯化PCL /角蛋白纳米纤维垫在生物医学领域可能会找到有希望的应用。
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