Gelatin Methacryloyl‐Based Tactile Sensors for Medical Wearables,Advanced Functional Materials

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Gelatin Methacryloyl‐Based Tactile Sensors for Medical Wearables
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2020-09-06 , DOI: 10.1002/adfm.202003601
Zhikang Li _{1,

2,

3,

4,

5,

6} , Shiming Zhang _{1,

2,

3} , Yihang Chen _{1,

2,

3} , Haonan Ling _{1,

2,

3,

7} , Libo Zhao _{4,

5,

6} , Guoxi Luo _{4,

5,

6} , Xiaocheng Wang _{1,

2,

3,

8} , Martin C Hartel _{1,

2,

3} , Hao Liu _{1,

2,

3,

9} , Yumeng Xue _{1,

2,

3,

10} , Reihaneh Haghniaz _{1,

2,

3} , KangJu Lee _{1,

2,

3} , Wujin Sun _{1,

2,

3} , Hanjun Kim _{1,

2,

3} , Junmin Lee _{1,

2,

3} , Yichao Zhao ₁₁ , Yepin Zhao _{3,

12} , Sam Emaminejad ₁₁ , Samad Ahadian _{1,

2,

3} , Nureddin Ashammakhi _{1,

2,

3,

13} , Mehmet R Dokmeci _{1,

2,

3,

13} , Zhuangde Jiang _{4,

5,

6} , Ali Khademhosseini _{1,

2,

3,

13,

14,

15}

Affiliation

Department of Bioengineering, University of California-Los Angeles, Los Angeles, CA 90095, USA.
Center for Minimally Invasive Therapeutics (C-MIT), University of California-Los Angeles, Los Angeles, CA 90095, USA.
California NanoSystems Institute, University of California-Los Angeles, Los Angeles, CA 90095, USA.
School of Mechanical Engineering, Xi'an Jiaotong University, Xi'an, 710049, China.
State Key Laboratory for Manufacturing Systems Engineering, Xi'an Jiaotong University, Xi'an, 710049, China.
International Joint Laboratory for Micro/Nano Manufacturing and Measurement Technologies, Xi'an Jiaotong University, Xi'an, 710049, China.
Department of Mechanical and Aerospace Engineering, University of California-Los Angeles, Los Angeles, CA 90095, USA.
School of Mechanical Engineering, Zhejiang University of Technology, Hangzhou, Zhejiang 310000, China.
Ministry of education key laboratory of biomedical information engineering, Xi'an Jiaotong University, Xi'an 710049, China.
Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China.
Department of Electrical and Computer Engineering, University of California-Los Angeles, Los Angeles, CA 90095, USA.
Department of Materials Science and Engineering, University of California-Los Angeles, Los Angeles, CA 90095, USA.
Department of Radiology, University of California-Los Angeles, Los Angeles, CA 90095, USA.
Department of Chemical and Biomolecular Engineering, University of California-Los Angeles, Los Angeles, CA 90095, USA.
Terasaki Institute for Biomedical Innovation, Los Angeles, CA 90024, USA.

Gelatin methacryloyl (GelMA) is a widely used hydrogel with skin‐derived gelatin acting as the main constituent. However, GelMA has not been used in the development of wearable biosensors, which are emerging devices that enable personalized healthcare monitoring. This work highlights the potential of GelMA for wearable biosensing applications by demonstrating a fully solution‐processable and transparent capacitive tactile sensor with microstructured GelMA as the core dielectric layer. A robust chemical bonding and a reliable encapsulation approach are introduced to overcome detachment and water‐evaporation issues in hydrogel biosensors. The resultant GelMA tactile sensor shows a high‐pressure sensitivity of 0.19 kPa⁻¹ and one order of magnitude lower limit of detection (0.1 Pa) compared to previous hydrogel pressure sensors owing to its excellent mechanical and electrical properties (dielectric constant). Furthermore, it shows durability up to 3000 test cycles because of tough chemical bonding, and long‐term stability of 3 days due to the inclusion of an encapsulation layer, which prevents water evaporation (80% water content). Successful monitoring of various human physiological and motion signals demonstrates the potential of these GelMA tactile sensors for wearable biosensing applications.

中文翻译：

用于医疗可穿戴设备的明胶甲基丙烯酰基触觉传感器

甲基丙烯酰明胶（GelMA）是一种广泛使用的水凝胶，以皮肤来源的明胶为主要成分。然而，GelMA 尚未用于可穿戴生物传感器的开发，可穿戴生物传感器是实现个性化医疗保健监测的新兴设备。这项工作通过展示以微结构 GelMA 作为核心介电层的完全可溶液加工的透明电容式触觉传感器，凸显了 GelMA 在可穿戴生物传感应用中的潜力。引入了强大的化学键合和可靠的封装方法来克服水凝胶生物传感器中的脱离和水蒸发问题。所得的 GelMA 触觉传感器由于其优异的机械和电气性能（介电常数）而表现出 0.19 kPa ^-1的高压灵敏度，与之前的水凝胶压力传感器相比，检测限低一个数量级（0.1 Pa）。此外，由于坚韧的化学键合，它具有高达 3000 个测试周期的耐用性，并且由于包含可防止水分蒸发（含水量 80%）的封装层，因此具有 3 天的长期稳定性。对各种人体生理和运动信号的成功监测证明了这些 GelMA 触觉传感器在可穿戴生物传感应用中的潜力。

更新日期：2020-09-06

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