Tetrahedron ( IF 2.1 ) Pub Date : 2020-09-06 , DOI: 10.1016/j.tet.2020.131553
Moshood O Ganiu 1 , Binod Nepal 1 , Joshua P Van Houten 1 , Rendy Kartika 1
This review article highlights selected advances in triphosgene-enabled organic synthetic reactions that were reported in the decade of 2010–2019. Triphosgene is a versatile reagent in organic synthesis. It serves as a convenient substitute for the toxic phosgene gas. Despite its first known preparation in the late 19th century, the upward surge in the development of organic reactions using triphosgene interestingly began only three decades ago. Despite the relatively short history, triphosgene has been proven to be very useful in facilitating the preparation of a vast scope of value-added compounds, such as organohalides, acid chlorides, isocyanates, carbonyl addition adducts, heterocycles, among others. Furthermore, applications of triphosgene in complex molecules synthesis, polymer synthesis, and other techniques, such as flow chemistry and solid phase synthesis, have also emerged in the literature.
中文翻译:
三光气及其在有机反应中的应用十年回顾
这篇综述文章重点介绍了 2010-2019 年十年间报道的三光气有机合成反应的部分进展。三光气是有机合成中的通用试剂。它可以作为有毒光气的便捷替代品。尽管其首次已知的制备方法是在 19 世纪末,但有趣的是,利用三光气进行有机反应的发展仅在三十年前才开始出现。尽管历史相对较短,但三光气已被证明在促进大量增值化合物的制备方面非常有用,例如有机卤化物、酰基氯、异氰酸酯、羰基加成物、杂环化合物等。此外,三光气在复杂分子合成、聚合物合成以及其他技术(例如流动化学和固相合成)中的应用也已出现在文献中。