<br>环状 RNA-miRNA 轴：一种特殊的 RNA 特征调节转录组作为 OSCC 的潜在生物标志物,Molecular Therapy - Nucleic Acids

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环状 RNA-miRNA 轴：一种特殊的 RNA 特征调节转录组作为 OSCC 的潜在生物标志物
Molecular Therapy - Nucleic Acids ( IF 6.5 ) Pub Date : 2020-09-06 , DOI: 10.1016/j.omtn.2020.09.001
Ramanathan Saikishore ₁ , Palanivel Velmurugan ₂ , Dhandapani Ranjithkumar ₁ , Ragunathan Latha ₃ , Thangavelu Sathiamoorthi ₁ , Ashokbabu Arun ₁ , Arumugam Veera Ravi ₂ , Subpiramaniyam Sivakumar ₄

Affiliation

口腔鳞状细胞癌（OSCC）是一种由口腔上皮引起的高度复发性癌症，这是由于烟草、吸烟、咀嚼槟榔和饮酒等病因因素导致突变变化的结果。据观察，OSCC 的发生普遍发生在太平洋国家的不同地区和大多数亚洲国家。尽管口腔可及，但 OSCC 在致病性肿瘤淋巴结转移 pTNM （III-IV）的极晚期被诊断出来，导致个体预后不良。因此，做出明确、早期和有效的诊断很重要。由于组学研究的发展，在唾液中检测到的蛋白质、转录元件、代谢产物甚至微生物群落的存在有助于我们选择生物标志物，由于样本采集的可用性和非侵入性，这是一个特别令人兴奋的潜力。自从通过 Sanger 测序发现环状 RNA （circRNA）以来，据报道它在包括癌症在内的多种人类疾病中起着关键作用。circRNA 在调节 mRNA 表达方面起 microRNA （miRNA）海绵的作用，形成 circRNA-miRNA 调节轴。在 OSCC 的情况下，不同 circRNA 的过表达同时表现出肿瘤进展和肿瘤抑制作用。

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The Circular RNA-miRNA Axis: A Special RNA Signature Regulatory Transcriptome as a Potential Biomarker for OSCC

Oral squamous cell carcinoma (OSCC) is a highly recurrent form of cancer arising from the oral epithelium, which is the result of mutational change due to etiological factors such as tobacco, smoking, chewing of areca nuts, and alcohol consumption. OSCC occurrence has been observed to be prevalent in different regions of Pacific countries and in most Asian countries. Despite the accessibility of the oral cavity, OSCC is diagnosed at an extremely late stage of pathogenic tumor node metastasis pTNM (III–IV), resulting in a poor prognosis for the individual. Therefore, it is important to make definitive, early, and efficient diagnoses. Owing to the development of omic-natured studies, the presence of proteins, transcribed elements, metabolic products, and even microflora detected in saliva helps us to select biomarkers, which is an especially exciting potential because of the availability and the non-invasive nature of sample collection. Since the discovery of circular RNA (circRNA) by Sanger sequencing, it has been reported to play a pivotal role in several human diseases, including cancer. circRNA functions as a microRNA (miRNA) sponge in the regulation of mRNA expression, forming the circRNA-miRNA regulatory axis. In the case of OSCC, overexpression of different circRNAs exhibits both tumor-progressive and tumor-suppressive effects.

更新日期：2020-09-06

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