Synthesis of CF3-Substituted 1,6-Dihydropyridazines by Copper-Promoted Cascade Oxidation/Cyclization of Trifluoromethylated Homoallylic N-Acylhydrazines.,The Journal of Organic Chemistry

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Synthesis of CF3-Substituted 1,6-Dihydropyridazines by Copper-Promoted Cascade Oxidation/Cyclization of Trifluoromethylated Homoallylic N-Acylhydrazines.
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2020-09-03 , DOI: 10.1021/acs.joc.0c01568
Tianyu Yang ₁ , Zhoubin Deng ₁ , Ke-Hu Wang ₁ , Pengfei Li ₁ , Danfeng Huang ₁ , Yingpeng Su ₁ , Yulai Hu _{1,

2}

Affiliation

A highly efficient strategy for the construction of CF₃-substituted 1,6-dihydropyridazines has been developed by cascade oxidation/cyclization of trifluoromethylated N-acylhydrazines. The produced 1,6-dihydropyridazines could be easily transformed to 3-trifluoromethyl pyridazine derivatives. Some of the 1,6-dihydropyridazines exhibited aggregation-induced emission (AIE). DFT calculations were conducted to explain the mechanism.

中文翻译：

三氟甲基化均烯丙基N-酰基肼的铜促进的级联氧化/环化反应合成CF3取代的1,6-二氢哒嗪。

通过三氟甲基化的N-酰基肼的级联氧化/环化，已经开发出一种构造CF _3-取代的1，6-二氢哒嗪的高效策略。产生的1，6-二氢哒嗪可以很容易地转化为3-三氟甲基哒嗪衍生物。一些1,6-二氢哒嗪显示出聚集诱导的发射（AIE）。进行了DFT计算以解释该机理。

更新日期：2020-10-02

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