Nanomaterials-based photothermal therapy and its potentials in antibacterial treatment,Journal of Controlled Release

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Nanomaterials-based photothermal therapy and its potentials in antibacterial treatment
Journal of Controlled Release ( IF 10.5 ) Pub Date : 2020-09-01 , DOI: 10.1016/j.jconrel.2020.08.055
Yuan Chen ₁ , Yujie Gao ₁ , Yue Chen ₂ , Liu Liu ₃ , Anchun Mo ₂ , Qiang Peng ₄

Affiliation

With the prevalence of antibiotic-resistant bacteria, novel antibacterial strategies are urgently needed. In recent years, several antibiotics-independent physical approaches have attracted high attention and interests. Among those approaches, photothermal therapy (PTT), a novel non-invasive therapeutic technique, has exhibited great potentials in dealing with drug-resistant bacteria and bacterial biofilms. Photothermal agents (PTAs), which are either nanomaterials themselves or small molecules loaded in nanoparticles, are the essential element for PTT. How to deliver PTAs in a controlled manner is of great importance for high-efficiency and low-toxicity PTT. Therefore, a comprehensive understanding of various PTAs is required for the better application of PTT in antibacterial treatment. Herein, the physicochemical properties and antibacterial PTT of five types of PTAs are summarized. In addition, the PTT-involved multifunctional theranostics nanoplatforms and the potential approaches for reducing the side effects of PTT (such as targeted delivery and controlled release of PTAs) are also discussed.

中文翻译：

基于纳米材料的光热疗法及其在抗菌治疗中的潜力

随着抗生素耐药细菌的普遍存在，迫切需要新的抗菌策略。近年来，几种不依赖抗生素的物理方法引起了高度关注和兴趣。其中，光热疗法（PTT）作为一种新型的非侵入性治疗技术，在处理耐药细菌和细菌生物膜方面表现出巨大的潜力。光热剂 (PTA) 既可以是纳米材料本身，也可以是纳米颗粒中负载的小分子，是 PTT 的基本要素。如何以可控的方式递送PTA对于高效、低毒的PTT具有重要意义。因此，为了更好地应用PTT在抗菌治疗中，需要对各种PTA进行全面的了解。本文总结了五种 PTA 的理化性质和抗菌 PTT。此外，还讨论了涉及 PTT 的多功能治疗诊断纳米平台和减少 PTT 副作用的潜在方法（例如 PTA 的靶向递送和控释）。

更新日期：2020-09-01

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