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Salivary Creatinine Detection Using a Cu(I)/Cu(II) Catalyst Layer of a Supercapacitive Hybrid Sensor: A Wireless IoT Device To Monitor Kidney Diseases for Remote Medical Mobility
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2020-08-27 , DOI: 10.1021/acsbiomaterials.0c00864 Surachate Kalasin 1 , Pantawan Sangnuang 2 , Porntip Khownarumit 2 , I. Ming Tang 3 , Werasak Surareungchai 1, 4
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2020-08-27 , DOI: 10.1021/acsbiomaterials.0c00864 Surachate Kalasin 1 , Pantawan Sangnuang 2 , Porntip Khownarumit 2 , I. Ming Tang 3 , Werasak Surareungchai 1, 4
Affiliation
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The stress-free electrochemical-based sensor equipped with the Internet of Things (IoT) device for salivary creatinine determination was fabricated for point-of-care (POC) diagnosis of advanced kidney disorders. Beneficial and real-time data readout for preventive diagnosis and clinical evaluation of chronic kidney diseases (CKD) at different stages and renal dysfunction can be acquired by noninvasive monitoring of the creatinine amounts in saliva. The direct determination and real-time response of salivary creatinine can be attained using the supercapacitor-based sensor of cuprous oxide nanoparticles entrapped by the synergistically cross-linked poly(acrylic acid) (PAA) gel–Cu2+ and Nafion perfluorinated membrane fabricated on a screen-printed carbon electrode (SPCE). Here, we demonstrated that the degree of renal illness could be evaluated using salivary creatinine detection via a catalytic mechanism as Cu2+ ions bound irreversibly with C═N functional groups of creatinine. Besides, the computer simulation was performed to study the interaction between 5 functional groups of creatinine toward acrylic gel–Cu2+. The linear increment between the obtained anodic currents and creatinine concentrations varying from 1 to 2000 μM was accomplished with a selectivity efficiency of 97.2%. Nyquist plots obtained by electrochemical impedance spectroscopy (EIS) validated that the increment of impedance changes strongly dependent on the amount of detected creatinine both in artificial and in human saliva. The porosity features were observed in this interconnected nanocomposite and correlated with Nafion doping. Successively, the friendly portable device was invented and integrated saliva sampling with miniaturized, low-cost IoT electronics of world-location mapping, representing the first remote medical sensor focusing on salivary creatinine sensing.
中文翻译：
使用超级电容混合传感器的Cu（I）/ Cu（II）催化剂层进行唾液肌酐检测：无线IoT设备，用于监测肾脏疾病以实现远程医疗移动
配备物联网（IoT）设备的无应力电化学传感器，用于唾液肌酐测定，可用于晚期肾脏疾病的即时诊断（POC）诊断。可以通过无创监测唾液中肌酐的量来获取有益和实时的数据，以进行慢性肾脏病（CKD）在不同阶段的预防性诊断和临床评估。唾液肌酐的直接测定和实时反应可以通过协同交联的聚丙烯酸（PAA）凝胶-Cu 2+包裹的氧化亚铜纳米粒子的基于超级电容器的传感器来实现。在丝网印刷的碳电极（SPCE）上制造的Nafion全氟化膜。在这里，我们证明了唾液肌酐的检测可以通过催化机制评估肾脏疾病的程度，因为Cu 2+离子不可逆地与肌酐的C═N官能团结合。此外，还进行了计算机模拟，研究了肌酸酐的5个官能团与丙烯酸凝胶Cu 2+之间的相互作用。所获得的阳极电流与肌酸酐浓度之间的线性增量在1至2000μM之间变化，选择性效率为97.2％。通过电化学阻抗谱（EIS）获得的Nyquist图证实，在人工唾液和人唾液中，阻抗的变化强烈依赖于检测到的肌酸酐的量。在该互连的纳米复合材料中观察到孔隙率特征，并且与Nafion掺杂相关。后来，发明了这种友好的便携式设备，并将唾液采样与世界各地定位的微型，低成本IoT电子设备集成在一起，代表了首个专注于唾液肌酐传感的远程医疗传感器。
更新日期：2020-10-12
中文翻译：
使用超级电容混合传感器的Cu（I）/ Cu（II）催化剂层进行唾液肌酐检测：无线IoT设备，用于监测肾脏疾病以实现远程医疗移动
配备物联网（IoT）设备的无应力电化学传感器，用于唾液肌酐测定，可用于晚期肾脏疾病的即时诊断（POC）诊断。可以通过无创监测唾液中肌酐的量来获取有益和实时的数据，以进行慢性肾脏病（CKD）在不同阶段的预防性诊断和临床评估。唾液肌酐的直接测定和实时反应可以通过协同交联的聚丙烯酸（PAA）凝胶-Cu 2+包裹的氧化亚铜纳米粒子的基于超级电容器的传感器来实现。在丝网印刷的碳电极（SPCE）上制造的Nafion全氟化膜。在这里，我们证明了唾液肌酐的检测可以通过催化机制评估肾脏疾病的程度，因为Cu 2+离子不可逆地与肌酐的C═N官能团结合。此外，还进行了计算机模拟，研究了肌酸酐的5个官能团与丙烯酸凝胶Cu 2+之间的相互作用。所获得的阳极电流与肌酸酐浓度之间的线性增量在1至2000μM之间变化，选择性效率为97.2％。通过电化学阻抗谱（EIS）获得的Nyquist图证实，在人工唾液和人唾液中，阻抗的变化强烈依赖于检测到的肌酸酐的量。在该互连的纳米复合材料中观察到孔隙率特征，并且与Nafion掺杂相关。后来，发明了这种友好的便携式设备，并将唾液采样与世界各地定位的微型，低成本IoT电子设备集成在一起，代表了首个专注于唾液肌酐传感的远程医疗传感器。
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