Abstract

1-Adamantylhydrazine can be a versatile intermediate for many biologically active compounds as adamantyl possesses a wide spectrum of medicinal properties. Described here is a detailed one-pot synthesis of 1-adamantylhydrazine, carried out on a milligram to gram scale, that steadily delivers a highly stable product used to carry out the synthesis of 1-(adamantan-1-yl)-1H-pyrazol-3-amine for bacterial studies. The reaction employs inexpensive, catalyst free, readily available starting materials. In the synthesis of 1-(adamantan-1-yl)-1H-pyrazol-3-amine, the use of a continuous extraction method allows for complete extraction of the target product into the organic layer and increases the overall percentage yield.

中文翻译：

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无催化剂，温度驱动的一锅法合成1-金刚烷基肼盐酸盐

摘要

1-金刚烷基肼可以作为许多生物活性化合物的通用中间体，因为金刚烷基具有广泛的药用特性。这里描述的是一个详细的一锅合成1- adamantylhydrazine的，在一个毫克进行以克规模，对于逐渐提供用于执行的1-合成（金刚烷-1-基）-1的高度稳定的产品ħ -吡唑-3-胺用于细菌研究。该反应使用便宜的，无催化剂的，容易获得的原料。在1-（金刚烷-1-基）-1 H-吡唑-3-胺的合成中，使用连续萃取方法可以将目标产物完全萃取到有机层中，并提高总产率。