Voltammetric Determination of an Anti‐rheumatoid Drug Acemetacin on Graphite Flake Paste Electrode and Glassy Carbon Electrode,Electroanalysis

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Voltammetric Determination of an Anti‐rheumatoid Drug Acemetacin on Graphite Flake Paste Electrode and Glassy Carbon Electrode
Electroanalysis ( IF 2.7 ) Pub Date : 2020-08-25 , DOI: 10.1002/elan.202060267
Natalia Festinger ₁ , Sylwia Smarzewska ₁ , Valentin Mirceski ₂ , Witold Ciesielski ₁

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In this study, a simple and sensitive square wave voltammetric procedure has been developed for the determination of acemetacin (ACM) at graphite flake paste electrode (GFPE) and glassy carbon electrode (GCE). Under optimized conditions, the dependence of ACM peak current on its concentration showed wide linear range: 0.03–1.0 μmol L⁻¹ and 0.7–15.0 μmol L⁻¹ at GFPE and GCE, respectively. The developed method was successfully applied for the determination of ACM in pharmaceuticals and spiked urine with satisfying recoveries. The electrochemical oxidation of ACM is an irreversible process controlled by mixed nature of the mass transfer process.

中文翻译：

石墨鳞片糊状电极和玻碳电极上的伏安法测定类风湿药醋胺

在这项研究中，已开发出一种简单而灵敏的方波伏安法测定石墨片状糊状电极（GFPE）和玻璃碳电极（GCE）上的醋乙酰胺（ACM）。在优化条件下，ACM峰值电流对其浓度的依赖关系显示出很宽的线性范围：分别在GFPE和GCE处为0.03–1.0μmolL ^-1和0.7–15.0μmolL ^-1。该方法成功用于药物和加标尿中ACM的测定，回收率令人满意。ACM的电化学氧化是不可逆的过程，受传质过程的混合性质控制。

更新日期：2020-08-25

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