Lewis-Acid-Mediated Intramolecular Trifluoromethylthiolation of Alkenes with Phenols: Access to SCF3-Containing Chromane and Dihydrobenzofuran Compounds.,Organic Letters

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Lewis-Acid-Mediated Intramolecular Trifluoromethylthiolation of Alkenes with Phenols: Access to SCF3-Containing Chromane and Dihydrobenzofuran Compounds.
Organic Letters ( IF 4.9 ) Pub Date : 2020-08-25 , DOI: 10.1021/acs.orglett.0c02744
Xu-Feng Song ₁ , Tong-Mei Ding ₁ , Deng Zhu ₁ , Jie Huang ₁ , Zhi-Min Chen ₁

Affiliation

A Lewis-acid-mediated intramolecular trifluoromethylthiolation of alkenes with phenols that can offer direct access to SCF₃-containing chromane and dihydrobenzofuran compounds was disclosed for the first time. Numerous SCF₃-containing chromanes were obtained in moderate to good yields using γ-substituted 2-allyphenols as substrates. Meanwhile, various SCF₃-containing dihydrobenzofurans with oxa-quaternary centers were also delivered in moderate to good yields using β-substituted 2-allyphenols as substrates.

中文翻译：

路易斯与苯酚介导的烯烃分子内三氟甲基硫醇化：获得含SCF3的铬烷和二氢苯并呋喃化合物。

首次公开了路易斯酸介导的烯烃与酚的分子内三氟甲基硫醇化，该酚可以直接进入含SCF ₃的苯并二氢呋喃和二氢苯并呋喃化合物。使用γ-取代的2-烯丙基苯酚作为底物，以中等至良好的产率获得了许多含SCF ₃的苯并二氢吡喃。同时，还使用β-取代的2-烯丙基酚作为底物以中等至良好的产率递送了具有氧杂-季中心的各种含SCF ₃的二氢苯并呋喃。

更新日期：2020-09-05

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