电离辐射诱导的DNA双链断裂中DNA修复途径选择的决定因素。,BioMed Research International

当前位置： X-MOL 学术 › BioMed Res. Int. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

电离辐射诱导的DNA双链断裂中DNA修复途径选择的决定因素。
BioMed Research International ( IF 2.6 ) Pub Date : 2020-08-25 , DOI: 10.1155/2020/4834965
Lei Zhao ₁ , Chengyu Bao ₁ , Yuxuan Shang ₁ , Xinye He ₁ , Chiyuan Ma ₂ , Xiaohua Lei ₂ , Dong Mi ₃ , Yeqing Sun ₁

Affiliation

电离辐射（IR-）诱导的DNA双链断裂（DSB）被认为是有害的DNA损伤，对基因组稳定性构成严重威胁。主要的DNA修复途径，包括经典的非同源末端连接，同源重组，单链退火和替代末端连接，在抵抗和诱导IR诱导的DSB确保基因组完整性方面起着关键作用。如果未正确修复IR诱导的DNA DSB，则残留或未正确修复的DSB可能导致与某些人类疾病相关的基因组不稳定。尽管在研究IR诱导的DNA DSB修复的主要机制方面已作了许多努力，但仍不清楚是什么决定IR诱导的DNA DSB修复途径的选择。在这篇评论中我们讨论了IR诱导的DSB修复途径选择的机制如何在辐射细胞中起作用。我们首先简要描述主要DNA DSB修复途径和相关关键修复蛋白的主要机制。基于我们对IR诱导的DNA DSBs的特征和DSB修复细胞在辐射细胞中的调控机制的了解以及该领域的最新进展，我们重点介绍了确定IR诱导的DSB修复途径选择的主要因素和相关挑战。我们得出结论，IR诱导的DSBs的类型和分布，染色质状态，DNA末端结构和DNA末端切除是选择IR诱导的DNA DSB修复途径的主要决定因素。我们首先简要描述主要DNA DSB修复途径和相关关键修复蛋白的主要机制。基于我们对IR诱导的DNA DSBs的特征以及DSB修复细胞在辐射细胞中的调控机制的了解以及该领域的最新进展，我们重点介绍了确定IR诱导的DSB修复途径选择的主要因素和相关挑战。我们得出结论，IR诱导的DSBs的类型和分布，染色质状态，DNA末端结构和DNA末端切除是选择IR诱导的DNA DSB修复途径的主要决定因素。我们首先简要描述主要DNA DSB修复途径和相关关键修复蛋白的主要机制。基于我们对IR诱导的DNA DSBs的特征以及DSB修复细胞在辐射细胞中的调控机制的了解以及该领域的最新进展，我们重点介绍了确定IR诱导的DSB修复途径选择的主要因素和相关挑战。我们得出结论，IR诱导的DSBs的类型和分布，染色质状态，DNA末端结构和DNA末端切除是选择IR诱导的DNA DSB修复途径的主要决定因素。然后，我们重点介绍确定IR诱导的DSB修复途径选择的主要因素和相关挑战。我们得出结论，IR诱导的DSBs的类型和分布，染色质状态，DNA末端结构和DNA末端切除是选择IR诱导的DNA DSB修复途径的主要决定因素。然后，我们重点介绍确定IR诱导的DSB修复途径选择的主要因素和相关挑战。我们得出结论，IR诱导的DSBs的类型和分布，染色质状态，DNA末端结构和DNA末端切除是选择IR诱导的DNA DSB修复途径的主要决定因素。

"点击查看英文标题和摘要"

The Determinant of DNA Repair Pathway Choices in Ionising Radiation-Induced DNA Double-Strand Breaks.

Ionising radiation- (IR-) induced DNA double-strand breaks (DSBs) are considered to be the deleterious DNA lesions that pose a serious threat to genomic stability. The major DNA repair pathways, including classical nonhomologous end joining, homologous recombination, single-strand annealing, and alternative end joining, play critical roles in countering and eliciting IR-induced DSBs to ensure genome integrity. If the IR-induced DNA DSBs are not repaired correctly, the residual or incorrectly repaired DSBs can result in genomic instability that is associated with certain human diseases. Although many efforts have been made in investigating the major mechanisms of IR-induced DNA DSB repair, it is still unclear what determines the choices of IR-induced DNA DSB repair pathways. In this review, we discuss how the mechanisms of IR-induced DSB repair pathway choices can operate in irradiated cells. We first briefly describe the main mechanisms of the major DNA DSB repair pathways and the related key repair proteins. Based on our understanding of the characteristics of IR-induced DNA DSBs and the regulatory mechanisms of DSB repair pathways in irradiated cells and recent advances in this field, We then highlight the main factors and associated challenges to determine the IR-induced DSB repair pathway choices. We conclude that the type and distribution of IR-induced DSBs, chromatin state, DNA-end structure, and DNA-end resection are the main determinants of the choice of the IR-induced DNA DSB repair pathway.

更新日期：2020-08-25

点击分享查看原文

点击收藏

公开下载

阅读更多本刊新发论文本刊介绍/投稿指南