Bacterial Vesicle-Cancer Cell Hybrid Membrane-Coated Nanoparticles for Tumor Specific Immune Activation and Photothermal Therapy.,ACS Applied Materials & Interfaces

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Bacterial Vesicle-Cancer Cell Hybrid Membrane-Coated Nanoparticles for Tumor Specific Immune Activation and Photothermal Therapy.
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2020-08-24 , DOI: 10.1021/acsami.0c13169
Dongdong Wang _{1,

2,

3} , Conghui Liu _{2,

4} , Shiquan You ₃ , Kai Zhang ₂ , Meng Li ₃ , Yu Cao ₂ , Changtao Wang ₃ , Haifeng Dong _{1,

2,

4} , Xueji Zhang _{2,

4}

Affiliation

Cell membrane camouflaged nanoparticles (NPs) have been increasingly explored to leverage natural cellular functions and adapt to various biomedical applications. Herein, we report an OMV-CC hybrid membrane, which consists of a bacterial outer membrane vesicle (OMV) and B16-F10 cancer cell (CC) membrane, and successfully coat it onto hollow polydopamine (HPDA) NPs. We harness the advantage of OMV immunotherapy together with HPDA-mediated photothermal therapy (PTT) to improve the antitumor efficacy toward melanoma. When injected intravenously via the tail vein, HPDA@[OMV-CC] NPs homogeneously target melanoma and activate the immune response by rapidly stimulating dendritic cell (DC) maturation in lymph nodes in the vaccinated mice. Our results show that the antitumor immune response and PTT reciprocally potentiate the therapeutic ability and fully eradicate melanoma without notable adverse effects. The homogeneous-target and immune activation hybrid biomimetic membrane provides the adaptability to various synergistic therapeutic and imaging applications by incorporating payload with application-specific functions.

中文翻译：

用于肿瘤特异性免疫激活和光热疗法的细菌囊泡-癌细胞混合膜包被纳米颗粒。

越来越多地探索了细胞膜伪装的纳米颗粒（NPs），以利用自然的细胞功能并适应各种生物医学应用。本文中，我们报道了一种OMV-CC混合膜，它由细菌外膜囊泡（OMV）和B16-F10癌细胞（CC）膜组成，并成功地将其包被到中空聚多巴胺（HPDA）NP上。我们利用OMV免疫疗法与HPDA介导的光热疗法（PTT）的优势来提高针对黑色素瘤的抗肿瘤功效。当通过尾静脉静脉注射时，HPDA @ [OMV-CC] NPs均匀靶向黑色素瘤并通过快速刺激接种小鼠的淋巴结中的树突状细胞（DC）成熟来激活免疫反应。我们的结果表明，抗肿瘤免疫应答和PTT相互增强了治疗能力并完全消除了黑色素瘤，而没有明显的不良影响。均质靶标和免疫活化混合仿生膜通过将有效载荷与特定应用功能结合在一起，提供了对各种协同治疗和成像应用的适应性。

更新日期：2020-08-24

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