Molecularly imprinted sol-gel electrochemical sensor for sildenafil based on a pencil graphite electrode modified by Preyssler heteropolyacid/gold nanoparticles/MWCNT nanocomposite,Microchimica Acta

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Molecularly imprinted sol-gel electrochemical sensor for sildenafil based on a pencil graphite electrode modified by Preyssler heteropolyacid/gold nanoparticles/MWCNT nanocomposite
Microchimica Acta ( IF 5.3 ) Pub Date : 2020-08-24 , DOI: 10.1007/s00604-020-04482-6
Mina Rouhani ₁ , Ahmad Soleymanpour ₁

Affiliation

An electrochemical sensor based on the imprinted sol-gel on pencil graphite electrode (PGE) modified with functionalized multiwalled carbon nanotube (MWCNT), gold nanoparticles (AuNPs), and Preyssler heteropolyacid (PHPA) nanohybrid was fabricated for the determination of trace amounts of sildenafil. The pencil graphite electrode was first deposited by the AuNPs@PHPA-MWCNT nanohybrids, and then, the modified electrode of MIP-sol-gel/AuNPs@PHPA-MWCNTs was prepared by the electrochemical method. The synthesized nanohybrids and prepared modified electrodes were characterized with FE-SEM, FTIR, EDX, XRD, and UV/Vis. Cyclic voltammetry, electrochemical impedance spectroscopy, and differential pulse voltammetry techniques were applied for the electrochemical analysis using the modified electrodes. By measuring the oxidation and reduction currents of the potassium ferricyanide probe, the efficiency of this sensor was evaluated for the detection of sildenafil. The anodic peak current was measured at 0.2 V vs. Ag/AgCl by differential pulse voltammetry in the potential range − 0.1 to 0.5 V (vs. Ag/AgCl). Under the optimum conditions, the current response for the detection of sildenafil was linear in two concentration ranges of 0.1–2 and 2–30 nM and the obtained limit of detection was 0.033 nM. The constructed sensor was used for the measurement of sildenafil in real samples.

中文翻译：

基于Preyssler杂多酸/金纳米颗粒/MWCNT纳米复合材料修饰的铅笔石墨电极的西地那非分子印迹溶胶-凝胶电化学传感器

制备了一种基于铅笔石墨电极 (PGE) 上印迹溶胶凝胶的电化学传感器，该电极经功能化多壁碳纳米管 (MWCNT)、金纳米粒子 (AuNPs) 和 Preyssler 杂多酸 (PHPA) 纳米杂化物修饰，用于测定痕量的西地那非. 首先通过AuNPs@PHPA-MWCNT纳米杂化物沉积铅笔状石墨电极，然后通过电化学方法制备MIP-sol-gel/AuNPs@PHPA-MWCNTs修饰电极。合成的纳米杂化物和制备的修饰电极用 FE-SEM、FTIR、EDX、XRD 和 UV/Vis 进行表征。循环伏安法、电化学阻抗谱和差分脉冲伏安法技术被应用于使用修饰电极的电化学分析。通过测量铁氰化钾探针的氧化和还原电流，评估了该传感器检测西地那非的效率。通过差分脉冲伏安法在电位范围 - 0.1 至 0.5 V（vs. Ag/AgCl）下测量阳极峰值电流为 0.2 V vs. Ag/AgCl。在最佳条件下，检测西地那非的电流响应在 0.1-2 和 2-30 nM 两个浓度范围内呈线性，获得的检测限为 0.033 nM。构建的传感器用于测量实际样品中的西地那非。在最佳条件下，检测西地那非的电流响应在 0.1-2 和 2-30 nM 两个浓度范围内呈线性，获得的检测限为 0.033 nM。构建的传感器用于测量实际样品中的西地那非。在最佳条件下，检测西地那非的电流响应在 0.1-2 和 2-30 nM 两个浓度范围内呈线性，获得的检测限为 0.033 nM。构建的传感器用于测量实际样品中的西地那非。

更新日期：2020-08-24

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