Libraries of Uniform Magnetic Multicore Nanoparticles with Tunable Dimensions for Biomedical and Photonic Applications.,ACS Applied Materials & Interfaces

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Libraries of Uniform Magnetic Multicore Nanoparticles with Tunable Dimensions for Biomedical and Photonic Applications.
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2020-08-19 , DOI: 10.1021/acsami.0c09778
Zhen Xiao ₁ , Qingbo Zhang ₁ , Xiaoting Guo ₁ , Jake Villanova ₁ , Yue Hu ₁ , Indrek Külaots ₂ , Daniel Garcia-Rojas ₃ , Wenhua Guo ₄ , Vicki L Colvin _{1,

2,

5}

Affiliation

Multicore iron oxide nanoparticles, also known as colloidal nanocrystal clusters, are magnetic materials with diverse applications in biomedicine and photonics. Here, we examine how both of their characteristic dimensional features, the primary particle and sub-micron colloid diameters, influence their magnetic properties and performance in two different applications. The characterization of these basic size-dependent properties is enabled by a synthetic strategy that provides independent control over both the primary nanocrystal and cluster dimensions. Over a wide range of conditions, electron microscopy and X-ray diffraction reveal that the oriented attachment of smaller nanocrystals results in their crystallographic alignment throughout the entire superstructure. We apply a sulfonated polymer with high charge density to prevent cluster aggregation and conjugate molecular dyes to particle surfaces so as to visualize their collection using handheld magnets. These libraries of colloidal clusters, indexed both by primary nanocrystal dimension (d_p) and overall cluster diameter (D_c), form magnetic photonic crystals with relatively weak size-dependent properties. In contrast, their performance as MRI T₂ contrast agents is highly sensitive to cluster diameter, not primary particle size, and is optimized for materials of 50 nm diameter (r₂ = 364 mM^–1 s^–1). These results exemplify the relevance of dimensional control in developing applications for these versatile materials.

中文翻译：

具有可调尺寸的均匀磁性多核纳米粒子库，用于生物医学和光子学应用。

多核氧化铁纳米粒子，也称为胶体纳米晶体簇，是在生物医学和光子学中有多种应用的磁性材料。在这里，我们研究了它们的特征尺寸特征，初级颗粒和亚微米胶体直径如何在两种不同的应用中影响它们的磁性能和性能。这些基本的尺寸依赖性特性的表征可通过合成策略实现，该策略可对初级纳米晶体和团簇尺寸进行独立控制。在宽范围的条件下，电子显微镜和X射线衍射表明，较小的纳米晶体的定向附着导致其在整个上部结构中的晶体学排列。我们使用具有高电荷密度的磺化聚合物来防止团簇聚集和将分子染料共轭到颗粒表面，以便使用手持式磁体可视化它们的收集。这些胶体簇的库，均由初级纳米晶体尺寸索引（d _p）和整体簇直径（D _c）形成了磁性光子晶体，具有相对较弱的尺寸依赖性。相比之下，它们作为MRI T ₂造影剂的性能对团簇直径高度敏感，而不是初级粒径，并且针对直径50 nm的材料进行了优化（r ₂ = 364 mM ^–1 s ^–1）。这些结果证明了尺寸控制在这些通用材料的开发应用中的相关性。

更新日期：2020-09-16

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