The role of ubiquitinase in B cell development and function,Journal of Leukocyte Biology

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The role of ubiquitinase in B cell development and function
Journal of Leukocyte Biology ( IF 3.6 ) Pub Date : 2020-08-20 , DOI: 10.1002/jlb.1mr0720-185rr
Tong Zhang ₁ , Jianxuan Sun ₁ , Jiali Cheng ₂ , Wei Yin ₃ , Jingwen Li ₄ , Heather Miller ₅ , Andrés A Herrada ₆ , Heng Gu ₁ , Hongmei Song ₇ , Yan Chen ₈ , Quan Gong _{9,

10} , Chaohong Liu ₁

Affiliation

Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Department of hematology, Tongji Hospital, Tongji Medical college, Huazhong University of Science and Technology, Wuhan, China.
Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Department of hematology, Wuhan Union Hospital, Tongji Medical college, Huazhong University of Science and Technology, Wuhan, China.
Department of Intracellular Pathogens, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
Lymphatic and Inflammation Research Laboratory, Facultad de Ciencias de la Salud, Instituto de Ciencias Biomédicas, Universidad Autónoma de Chile, Talca, Chile.
Department of Pediatrics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No 1, Shuaifuyuan, Dongcheng District, Beijing, China.
The Second Department of Pediatrics, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.
Department of Immunology, School of Medicine, Yangtze University, Jingzhou, China.
Clinical Molecular Immunology Center, School of Medicine, Yangtze University, Jingzhou, China.

Ubiquitinases are a select group of enzymes that modify target proteins through ubiquitination, which plays a crucial role in the regulation of protein degradation, location, and function. B lymphocytes that originated from bone marrow hematopoietic stem cells (HSC), exert humoral immune functions by differentiating into plasma cells and producing antibodies. Previous studies have shown that ubiquitination is involved in the regulation of the cell cycle and signal transduction important for B lymphocyte development and function. In this review, how ubiquitinases regulate B cell development, activation, apoptosis, and proliferation is discussed, which could help in understanding the physiological processes and diseases related to B cells and also provides potential new targets for further studies.

中文翻译：

泛素酶在B细胞发育和功能中的作用

泛素化酶是通过泛素化修饰靶蛋白的一组精选酶，其在调节蛋白降解，位置和功能中起关键作用。源自骨髓造血干细胞（HSC）的B淋巴细胞通过分化为浆细胞并产生抗体来发挥体液免疫功能。先前的研究表明，泛素化参与了对B淋巴细胞发育和功能重要的细胞周期调节和信号转导。在这篇综述中，讨论了泛素化酶如何调节B细胞的发育，激活，凋亡和增殖，这可以帮助理解与B细胞有关的生理过程和疾病，并为进一步的研究提供潜在的新靶标。

更新日期：2020-08-20

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