Adhesive Hydrogel Patch with Enhanced Strength and Adhesiveness to Skin for Transdermal Drug Delivery,Advanced Functional Materials

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Adhesive Hydrogel Patch with Enhanced Strength and Adhesiveness to Skin for Transdermal Drug Delivery
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2020-08-19 , DOI: 10.1002/adfm.202004407
Hooyeon Jung ₁ , Min Kyung Kim ₂ , Jun Yup Lee ₁ , Seung Woo Choi ₂ , Jaeyun Kim _{1,

2,

3,

4}

Affiliation

Transdermal drug delivery patches based on hydrogels are widely used for the transdermal delivery of diverse drugs. However, most hydrogels do not exhibit adequate adhesiveness to skin surface. Herein, tissue adhesive hydrogels consisting of polyacrylamide/polydopamine (PAM/PDA) hydrogels embedded with extra‐large pore mesoporous silica nanoparticles (XL‐MSNs) are proposed based on the synergy of cohesive and adhesive properties. The incorporation of XL‐MSNs leads to enhanced strength and adhesiveness to skin tissue due to an increased cohesive property derived from molecular interactions between XL‐MSNs and polymer chains. The application of XL‐MSNs to the hydrogel–skin tissue interface leads to a further enhanced adhesiveness due to the adhesive gluing role of XL‐MSNs on the interface. The optimized condition enables a 4.9‐fold increase in adhesion energy on the porcine skin tissue, compared to the control PAM/PDA patch. Strong adhesion is achieved immediately after the hydrogel patch is attached onto the skin as well as the surfaces of other organs. Finally, transdermal drug delivery through porcine skin is demonstrated by using the hydrogel patch, with a model drug loaded in the XL‐MSNs embedded in the patch. These observations indicate a simple but highly effective strategy for preparing a highly adhesive hydrogel patch for transdermal drug delivery.

中文翻译：

具有增强的强度和对皮肤的粘附性的粘合性水凝胶贴剂，用于透皮给药

基于水凝胶的透皮药物递送贴剂被广泛用于多种药物的透皮递送。但是，大多数水凝胶对皮肤表面没有足够的粘附性。在本文中，基于内聚和粘合性能的协同作用，提出了由聚丙烯酰胺/聚多巴胺（PAM / PDA）水凝胶与超大孔介孔二氧化硅纳米颗粒（XL-MSNs）嵌入组成的组织粘合水凝胶。由于XL‐MSN与聚合物链之间的分子相互作用而产生的内聚性增强，因此XL‐MSN的引入可增强强度和对皮肤组织的粘附性。由于XL-MSNs在界面上的胶粘作用，将XL-MSNs应用于水凝胶-皮肤组织界面可进一步增强粘合性。优化的条件使一个4。与对照PAM / PDA贴片相比，猪皮肤组织上的附着力增加了9倍。在将水凝胶贴剂附着在皮肤以及其他器官的表面上后，即可立即获得牢固的附着力。最后，通过使用水凝胶贴剂证明了通过猪皮肤的透皮药物递送，其中模型药物装载在嵌入贴剂的XL-MSN中。这些观察结果表明了制备用于透皮药物递送的高粘附性水凝胶贴剂的简单但高效的策略。并在嵌入补丁的XL-MSN中装入模型药物。这些观察结果表明了制备用于透皮药物递送的高粘附性水凝胶贴剂的简单但高效的策略。并在嵌入补丁的XL-MSN中装入模型药物。这些观察结果表明了制备用于透皮药物递送的高粘附性水凝胶贴剂的简单但高效的策略。

更新日期：2020-10-17

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