Acyl Radicals from α-Keto Acids Using a Carbonyl Photocatalyst: Photoredox-Catalyzed Synthesis of Ketones.,Organic Letters

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Acyl Radicals from α-Keto Acids Using a Carbonyl Photocatalyst: Photoredox-Catalyzed Synthesis of Ketones.
Organic Letters ( IF 4.9 ) Pub Date : 2020-08-18 , DOI: 10.1021/acs.orglett.0c02351
Da-Liang Zhu ₁ , Qi Wu ₁ , David James Young ₂ , Hao Wang ₁ , Zhi-Gang Ren ₁ , Hong-Xi Li ₁

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Acyl radicals have been generated from α-keto acids using inexpensive and commercially available 2-chloro-thioxanthen-9-one as the photoredox catalyst under visible light illumination. These reactive species added to olefins or coupled with aryl halides via a bipyridyl-stabilized Ni(II) catalyst, enabling easy access to a diverse range of ketones. This reliable, atom-economical, and eco-friendly protocol is compatible with a wide range of functional groups.

中文翻译：

使用羰基光催化剂从α-酮酸制得的酰基自由基：光氧化还原催化的酮合成。

在可见光照射下，使用廉价且可商购的2-氯-噻吨酮-9-作为光氧化还原催化剂，已由α-酮酸生成了酰基基团。这些反应性物质通过联吡啶基稳定的Ni（II）催化剂添加到烯烃中或与芳基卤化物偶合，可轻松获得各种酮。这种可靠，原子经济且环保的协议可与多种官能团兼容。

更新日期：2020-09-05

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