Acute stress disrupts intestinal homeostasis via GDNF‐RET,Cell Proliferation

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Acute stress disrupts intestinal homeostasis via GDNF‐RET
Cell Proliferation ( IF 5.9 ) Pub Date : 2020-08-17 , DOI: 10.1111/cpr.12889
Lin Lin _{1,

2} , Bingcheng Feng _{1,

2} , Ruchen Zhou _{1,

2} , Yi Liu _{1,

3} , Lixiang Li _{1,

2} , Kairuo Wang _{1,

2} , Yanbo Yu _{1,

2} , Chao Liu _{1,

2} , Xin Long _{1,

2} , Xiang Gu _{1,

2} , Bing Li _{1,

2} , Xiaojie Wang ₄ , Xiaoyun Yang _{1,

2} , Yingzi Cong ₅ , Xiuli Zuo _{1,

2} , Yanqing Li _{1,

2}

Affiliation

Enterochromaffin (EC) cells have been associated with functional gastrointestinal disorders such as IBS. Recently, we found that glial cell‐derived neurotrophic factor (GDNF)‐rearranged during transfection (RET) localized in EC cells in human colonic epithelia. Here, we examine the role of GDNF‐RET in the pathophysiology of diarrhoea‐predominant irritable bowel syndrome (IBS‐D).

中文翻译：

急性压力通过 GDNF-RET 破坏肠道稳态

肠嗜铬 (EC) 细胞与功能性胃肠道疾病如 IBS 相关。最近，我们发现胶质细胞衍生的神经营养因子 (GDNF) 在转染 (RET) 过程中重排，位于人结肠上皮的 EC 细胞中。在这里，我们检查了 GDNF-RET 在腹泻型肠易激综合征 (IBS-D) 病理生理学中的作用。

更新日期：2020-08-17

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